caa a22 4500 477084265 CHVBK 20180405111458.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/BF01919308 doi (NATIONALLICENCE)springer-10.1007/BF01919308 The plasma level of some amino acids and physical and mental fatigue [Elektronische Daten] [E. Newsholme, E. Blomstrand] Tryptophan is converted to 5-hydroxytryptamine (5-HT) in the brain and evidence is presented that an increase in the concentration of 5-HT can result in physical and mental fatigue during prolonged exercise. The entry of tryptophan in the brain is influenced by the plasma level of free tryptophan (that not bound to albumin) and, from competition for entry into brain, by the plasma level of branched chain amino acids. Hence, oral administration of branched chain amino acids could, theoretically, prevent the increase in 5-HT level during exercise and therefore delay physical and mental fatigue. Evidence in support of this hypothesis is presented. Birkhäuser Verlag, 1996 Tryptophan nationallicence 5-hydroxytryptamine nationallicence fatigue nationallicence branched chain amino acids nationallicence exercise nationallicence Newsholme E. Cellular Nutrition Research Group, Department of Biochemistry, University of Oxford, South Parks Road, OX1 3QU, Oxford, (UK) aut Blomstrand E. Pripps Research Laboratory, Pripps Bryggerier, Bromma, (Sweden) aut Experientia Birkhäuser-Verlag 52/5(1996-05-01), 413-415 0014-4754 52:5<413 1996 52 18 https://doi.org/10.1007/BF01919308 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01919308 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Newsholme E. Cellular Nutrition Research Group, Department of Biochemistry, University of Oxford, South Parks Road, OX1 3QU, Oxford, (UK) aut NATIONALLICENCE 700 1- Blomstrand E. Pripps Research Laboratory, Pripps Bryggerier, Bromma, (Sweden) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/5(1996-05-01), 413-415 0014-4754 52:5<413 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer