caa a22 4500 477084311 CHVBK 20180405111458.0 cr unu---uuuuu 170330e19960201xx s 000 0 eng 10.1007/BF01923366 doi (NATIONALLICENCE)springer-10.1007/BF01923366 Antiviral activities of anthraquinones, bianthrones and hypericin derivatives from lichens [Elektronische Daten] [P. Cohen, J. Hudson, G. Towers] The antiviral activities of some naturally occurring anthraquinones bianthrones, and hypericin derivatives were compared by the end-point CPE (viral cytopathic effects) method and plaque assays. Under optimal conditions of exposure to light, hypericin, 7,7′-dichlorohypericin and 5,7-dichloroemodin exhibited strong inhibitory activity against HSV-1 (herpes simplex virus type 1) in both assays. Partial inactivation of the virus was shown by emodin, 7-chloroemodin and 7-chloro-1-O-methylemodin; the bianthrones and other anthraquinones were found to be inactive. Antiviral activity appeared to be, positively correlated with increasing substitution of chlorine in the anthraquinone structure. In the absence of light, only hypericin and 7,7′-dichlorohypericin displayed detectable activity. Birkhäuser Verlag Basel, 1996 Antiviral activity nationallicence 7,7′-dichlorohypericin nationallicence 5,7-dichloroemodin nationallicence hypericin nationallicence anthraquinones nationallicence bianthrones nationallicence lichen nationallicence Nephroma laevigatum nationallicence Heterodermia obscurata nationallicence Cohen P. Department of Botany, University of British Columbia, V6T 1Z4, Vancouver, British Columbia, Canada aut Hudson J. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, (Canada) aut Towers G. Department of Botany, University of British Columbia, V6T 1Z4, Vancouver, British Columbia, Canada aut Experientia Birkhäuser-Verlag 52/2(1996-02-01), 180-183 0014-4754 52:2<180 1996 52 18 https://doi.org/10.1007/BF01923366 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01923366 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cohen P. Department of Botany, University of British Columbia, V6T 1Z4, Vancouver, British Columbia, Canada aut NATIONALLICENCE 700 1- Hudson J. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, (Canada) aut NATIONALLICENCE 700 1- Towers G. Department of Botany, University of British Columbia, V6T 1Z4, Vancouver, British Columbia, Canada aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/2(1996-02-01), 180-183 0014-4754 52:2<180 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer