caa a22 4500 477084338 CHVBK 20180405111458.0 cr unu---uuuuu 170330e19960201xx s 000 0 eng 10.1007/BF01923354 doi (NATIONALLICENCE)springer-10.1007/BF01923354 Antiperoxide effect of S-allyl cysteine sulfoxide, an insulin secretagogue, in diabetic rats [Elektronische Daten] [K. Augusti, C. Sheela] Treatment of alloxan diabetic rats with the antioxidant S-allyl cysteine sulfoxide (SACS) isolated from garlic (Allium sativum Linn)., ameliorated the diabetic condition almost to the same extent as did glibenclamide and insulin. In addition, SACS controlled lipid peroxidation better than the other two drugs. Furthermore, SACS significantly stimulated in vitro insulin secretion from B cells isolated from normal rats. Hence it can be surmised that the beneficial effects of SACS could be due to both its antioxidant and its secretagogue actions. The former effect is more predominant and the latter is only secondary. These effects highlight the therapeutic value of garlic, which is a component of many diets. Birkhäuser Verlag Basel, 1996 Antioxidant nationallicence S-ally cysteine sulfoxide nationallicence insulin secretagogue nationallicence albino rats nationallicence glibenclamide nationallicence malondialdehyde nationallicence hydroperoxide nationallicence supperoxide dismutase nationallicence Augusti K. Department of Biochemistry, University of Kerala, 695 581, Thiruvananthapuram, (India) aut Sheela C. Department of Biochemistry, University of Kerala, 695 581, Thiruvananthapuram, (India) aut Experientia Birkhäuser-Verlag 52/2(1996-02-01), 115-119 0014-4754 52:2<115 1996 52 18 https://doi.org/10.1007/BF01923354 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01923354 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Augusti K. Department of Biochemistry, University of Kerala, 695 581, Thiruvananthapuram, (India) aut NATIONALLICENCE 700 1- Sheela C. Department of Biochemistry, University of Kerala, 695 581, Thiruvananthapuram, (India) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/2(1996-02-01), 115-119 0014-4754 52:2<115 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer