caa a22 4500 477084362 CHVBK 20180405111459.0 cr unu---uuuuu 170330e19960201xx s 000 0 eng 10.1007/BF01923358 doi (NATIONALLICENCE)springer-10.1007/BF01923358 Nitric oxide-dependent blood-brain barrier permeability alteration in the rat brain [Elektronische Daten] [A. Shukla, M. Dikshit, R. Srimal] The role of nitric oxide (NO), a well known vasodilator, in the regulation of blood-brain barrier (BBB) permeability is not clear. Therefore, the present study was planned to assess the role of NO-releasing compounds like sodium nitroprusside (SNP) and the active metabolite of molsidomine, SIN-1, as well as a precursor of NO, L-arginine, on this physiological barrier. The permeability was assessed by using several tracers. All three agents increased the permeability of BBB to the tracer. The increase in permeability caused by L-arginine was not blocked by N-nitro-L-arginine methyl ester (L-NAME). L-Arginine-treated brains did not show an elevation of nitrite content, thus ruling out the possibility of NO generation and its involvement in BBB permeability alteration. It is concluded that NO itself causes an increase in the permeability of BBB. However arginine-induced opening is not NO mediated. Birkhäuser Verlag Basel, 1996 Blood-brain barrier nationallicence nitric oxide nationallicence arginine nationallicence sodium fluorescein nationallicence N-nitro L-arginine methyl ester nationallicence Shukla A. Pharmacology Division, Central Drug Research Institute, 226001, Lucknow, (India) aut Dikshit M. Pharmacology Division, Central Drug Research Institute, 226001, Lucknow, (India) aut Srimal R. Industrial Toxicology Research Centre, 226001, Lucknow, (India) aut Experientia Birkhäuser-Verlag 52/2(1996-02-01), 136-140 0014-4754 52:2<136 1996 52 18 https://doi.org/10.1007/BF01923358 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01923358 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shukla A. Pharmacology Division, Central Drug Research Institute, 226001, Lucknow, (India) aut NATIONALLICENCE 700 1- Dikshit M. Pharmacology Division, Central Drug Research Institute, 226001, Lucknow, (India) aut NATIONALLICENCE 700 1- Srimal R. Industrial Toxicology Research Centre, 226001, Lucknow, (India) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/2(1996-02-01), 136-140 0014-4754 52:2<136 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer