caa a22 4500 477084397 CHVBK 20180405111459.0 cr unu---uuuuu 170330e19960201xx s 000 0 eng 10.1007/BF01923357 doi (NATIONALLICENCE)springer-10.1007/BF01923357 A new approach to analysis of human sweating [Elektronische Daten] [M. Shimazu, T. Matsumoto, M. Kosaka, N. Ohwatari, K. Tsuchiya, Y. Ueyama, K. Urano, Y. Kataki, M. Saito] In human skin transplanted to the back of 3 strains of immuno-deficient mice the functin of the eccrine sweat glands of the human transplant was tested by topical intradermal application of pilocarine, adrenaline and atropine+pilocarpine. Sweat responses were observed in pre-selected fields of observation by means of video macroscope. The iodine strarch reaction served as an indicator for the appearance of seat sport and permitted the evaluation of areas wetted by sweat in the field of observation. Among 9 animals tested, the hybrids between the CB-17-scid mouse and the BALB/cA-nu mouse (BALB/cA-nu,scid) seemed to exhibit the most consistent seweating response to local pharmacological stimulation. According to histological examination, eccrine sweat glands were preserved in human skin trasplanted into the back skin of the BALB/cA-nu,scid mouse strain. the heterologous, human skin graft provides a novel model permitting, independent of the normal sweat gland innervation, the analysis of moecular receptors of sweat gland cells by which the actions of natural transmitters and pharmacological agents are transduced. Birkhäuser Verlag Basel, 1996 Human skin nationallicence heterologous transplant nationallicence immuno-deficient mouse nationallicence eccrine seating nationallicence pilocarpine nationallicence adrenaline nationallicence atropine nationallicence Shimazu M. Department of Environmental Physiology, Institute of Tropical Medicine, Nagasaki University, 852, Nagasaki, (Japan) aut Matsumoto T. Department of Environmental Physiology, Institute of Tropical Medicine, Nagasaki University, 852, Nagasaki, (Japan) aut Kosaka M. Department of Environmental Physiology, Institute of Tropical Medicine, Nagasaki University, 852, Nagasaki, (Japan) aut Ohwatari N. Department of Environmental Physiology, Institute of Tropical Medicine, Nagasaki University, 852, Nagasaki, (Japan) aut Tsuchiya K. Department of Environmental Physiology, Institute of Tropical Medicine, Nagasaki University, 852, Nagasaki, (Japan) aut Ueyama Y. Kanagawa Academy of Science and Technology, 213, Kanagawa, (Japan) aut Urano K. Kanagawa Academy of Science and Technology, 213, Kanagawa, (Japan) aut Kataki Y. Central Insititute for Experimental Animals, 213, Kanagawa, (Japan) aut Saito M. Central Insititute for Experimental Animals, 213, Kanagawa, (Japan) aut Experientia Birkhäuser-Verlag 52/2(1996-02-01), 131-135 0014-4754 52:2<131 1996 52 18 https://doi.org/10.1007/BF01923357 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01923357 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shimazu M. Department of Environmental Physiology, Institute of Tropical Medicine, Nagasaki University, 852, Nagasaki, (Japan) aut NATIONALLICENCE 700 1- Matsumoto T. Department of Environmental Physiology, Institute of Tropical Medicine, Nagasaki University, 852, Nagasaki, (Japan) aut NATIONALLICENCE 700 1- Kosaka M. Department of Environmental Physiology, Institute of Tropical Medicine, Nagasaki University, 852, Nagasaki, (Japan) aut NATIONALLICENCE 700 1- Ohwatari N. Department of Environmental Physiology, Institute of Tropical Medicine, Nagasaki University, 852, Nagasaki, (Japan) aut NATIONALLICENCE 700 1- Tsuchiya K. Department of Environmental Physiology, Institute of Tropical Medicine, Nagasaki University, 852, Nagasaki, (Japan) aut NATIONALLICENCE 700 1- Ueyama Y. Kanagawa Academy of Science and Technology, 213, Kanagawa, (Japan) aut NATIONALLICENCE 700 1- Urano K. Kanagawa Academy of Science and Technology, 213, Kanagawa, (Japan) aut NATIONALLICENCE 700 1- Kataki Y. Central Insititute for Experimental Animals, 213, Kanagawa, (Japan) aut NATIONALLICENCE 700 1- Saito M. Central Insititute for Experimental Animals, 213, Kanagawa, (Japan) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/2(1996-02-01), 131-135 0014-4754 52:2<131 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer