caa a22 4500 477084419 CHVBK 20180405111459.0 cr unu---uuuuu 170330e19960201xx s 000 0 eng 10.1007/BF01923363 doi (NATIONALLICENCE)springer-10.1007/BF01923363 2-Carboxyethylgermanium sesquioxide, a synthetic organogermanium compound, as an inducer of contrasuppressor T cells [Elektronische Daten] [K. Ikemoto, M. Kobayashi, T. Fukumoto, M. Morimatsu, R. Pollard, F. Suzuki] 2-Carboxyethylgermanium sesquioxide (Ge-132), a synthesized organogermanium compound with immunomodulaing activities, was shown to be an inducer of anti-suppressor T cells in normal mice. The suppressor cell activity of T6S cells, a clone of burn-induced CD8+ IL-4-producing suppressor T cells, was clearly inhibited when a mixed lymphocyte-tumor cell reaction of the clone was conducted with splenic mononuclear cells from mice treated orally with a 100 mg/kg dose of Ge-132. The activity of anti-suppressor cells was demonstrated in spleens of mice 2 days after treatment with Ge-132 and reached its peak on day 3. The anti-suppressor cells induced by the compound were of a contrasuppressor T cell-linage, because they were characterized as CD4+ CD28+ TCRα/β+ Vicia villosa lectin-adherent T cells. These cells produced IFN-γ but did not produce IL-2, IL-4, IL-6 or IL-10 in their culture fluids. CD4+ anti-suppressor T cells induced by Ge-132 may be different from other subsets of CD4+ T cells because Th1 and Th2 cells generated in our laboratory did not adhere toVicia villosa lectin-coated petri dishes, and each produced specific cytokines. Th1 cells produced IFN-γ and IL-2 while Th2 cells produce IL-4 and IL-10 in vitro. These results suggest that Ge-132 may be useful as an inducer of contrasuppressor T cells in immunocompromised individuals bearing suppressor T cells. To eliminate suppressor T cells from immunocompromised hosts may result in improved resistance from various opportunistic infections. Birkhäuser Verlag Basel, 1996 Organogermanium compound nationallicence contrasuppressor T cells nationallicence suppressor T cells nationallicence Ikemoto K. Department of Neurology, Yamaguchi University of Medical School, Yamaguchi, (Japan) aut Kobayashi M. Department of Internal Medicine, The University of Texas Medical Branch and Shriners Burns Institute, 301 University Blvd., 77555, Galveston, (Texas, USA) aut Fukumoto T. Department of Anatomy, Yamaguchi University of Medical School, Yamaguchi, (Japan) aut Morimatsu M. Department of Neurology, Yamaguchi University of Medical School, Yamaguchi, (Japan) aut Pollard R. Department of Internal Medicine, The University of Texas Medical Branch and Shriners Burns Institute, 301 University Blvd., 77555, Galveston, (Texas, USA) aut Suzuki F. Department of Internal Medicine, The University of Texas Medical Branch and Shriners Burns Institute, 301 University Blvd., 77555, Galveston, (Texas, USA) aut Experientia Birkhäuser-Verlag 52/2(1996-02-01), 159-166 0014-4754 52:2<159 1996 52 18 https://doi.org/10.1007/BF01923363 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01923363 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ikemoto K. Department of Neurology, Yamaguchi University of Medical School, Yamaguchi, (Japan) aut NATIONALLICENCE 700 1- Kobayashi M. Department of Internal Medicine, The University of Texas Medical Branch and Shriners Burns Institute, 301 University Blvd., 77555, Galveston, (Texas, USA) aut NATIONALLICENCE 700 1- Fukumoto T. Department of Anatomy, Yamaguchi University of Medical School, Yamaguchi, (Japan) aut NATIONALLICENCE 700 1- Morimatsu M. Department of Neurology, Yamaguchi University of Medical School, Yamaguchi, (Japan) aut NATIONALLICENCE 700 1- Pollard R. Department of Internal Medicine, The University of Texas Medical Branch and Shriners Burns Institute, 301 University Blvd., 77555, Galveston, (Texas, USA) aut NATIONALLICENCE 700 1- Suzuki F. Department of Internal Medicine, The University of Texas Medical Branch and Shriners Burns Institute, 301 University Blvd., 77555, Galveston, (Texas, USA) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/2(1996-02-01), 159-166 0014-4754 52:2<159 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer