caa a22 4500 477084443 CHVBK 20180405111459.0 cr unu---uuuuu 170330e19960201xx s 000 0 eng 10.1007/BF01923365 doi (NATIONALLICENCE)springer-10.1007/BF01923365 Unusual antimicrobial compounds from Aeollanthus buchnerianus [Elektronische Daten] [J. Dellar, M. Cole, P. Waterman] Using bioassay guided isolation, three novel 12 carbon polyoxygenated fatty acids and a novel abietane diterpene have been isolated from the the chloroform extract of aerial parts ofAeollanthus buchnerianus (Lamiaceae). Rigorous spectroscopic methods were used for compound identification. (Z,Z)-8ζ-acetoxy-5ζ-hydroxydodeca-2,6-dienoic acid and (Z,Z)-5ζ,8ζ-dihydroxydodeca-2,6-dienoic acid inhibited the spore germination ofCladosporium cucumerinum (both with Minimum Inhibitory Dose (MID) values of 1 μg) andAspergillus niger (MID 5 and 25 μg respectively). Further, they also reduced the hyphal growth ofPythium ultimum. (Z)-5ζ-hydroxy-6ζ,7ζ,8ζ-triacetoxydodeca-2-dienoic acid exhibited short term inhibition of the growth ofCladosporium cucumerinum. The novel abietane diterpenoid, (rel)-14α-acetoxyabiet-7-en-18-oic acid inhibited the growth of the gram positive bacteriaBacillus subtilis, staphylococcus aureus andStreptomyces scabies (MIC values 80, 20 and 20 μg ml−1 respectively). Birkhäuser Verlag Basel, 1996 Aeollanthus buchnerianus nationallicence Lamiaceae nationallicence dodecanoic acids nationallicence abietane diterpenes nationallicence antifungal and antibacterial bioactivity nationallicence Dellar J. Phytochemistry Research Laboratories, Department of Pharmaceutical Sciences, University of Strathclyde, 204 George Street, G1 1XW, Glasgow, (Scotland) aut Cole M. Forensic Science Unit, Department of Pure and Applied Chemistry, University of Strathclyde, G1 1XW, Glasgow, (Scotland) aut Waterman P. Phytochemistry Research Laboratories, Department of Pharmaceutical Sciences, University of Strathclyde, 204 George Street, G1 1XW, Glasgow, (Scotland) aut Experientia Birkhäuser-Verlag 52/2(1996-02-01), 175-179 0014-4754 52:2<175 1996 52 18 https://doi.org/10.1007/BF01923365 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01923365 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dellar J. Phytochemistry Research Laboratories, Department of Pharmaceutical Sciences, University of Strathclyde, 204 George Street, G1 1XW, Glasgow, (Scotland) aut NATIONALLICENCE 700 1- Cole M. Forensic Science Unit, Department of Pure and Applied Chemistry, University of Strathclyde, G1 1XW, Glasgow, (Scotland) aut NATIONALLICENCE 700 1- Waterman P. Phytochemistry Research Laboratories, Department of Pharmaceutical Sciences, University of Strathclyde, 204 George Street, G1 1XW, Glasgow, (Scotland) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/2(1996-02-01), 175-179 0014-4754 52:2<175 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer