caa a22 4500 477084494 CHVBK 20180405111500.0 cr unu---uuuuu 170330e19961001xx s 000 0 eng 10.1007/BF01920107 doi (NATIONALLICENCE)springer-10.1007/BF01920107 Role of protein kinase activity in apoptosis [Elektronische Daten] [M. Lavin, D. Watters, Q. Song] The transmission of signals from the plasma membrane to the nucleus involves a number of different pathways all of which have in common protein modification. The modification is primarily in the form of phosphorylation which leads to the activation of a series of protein kinases. It is now evident that these pathways are common to stimuli that lead to mitogenic and apoptotic responses. Even the same stimuli under different physiological conditions can cause either cell proliferation or apoptosis. Activation of specific protein kinases can in some circumstances protect against cell death, while in others it protects the cell against apoptosis. Some of the pathways involved lead to activation of transcription factors and the subsequent induction of genes involved in the process of cell death or proliferation. In other cases, such as for the tumour suppressor gene product p53, activation may be initiated both at the level of gene expression or through pre-existing proteins. Yet in others, while the initial steps in the pathway are ill-defined, it is clear that downstream activation of a series of cysteine proteases is instrumental in pushing the cell towards apoptosis. In this report we review the involvement of protein kinases at several different levels in the control of cell behavior. Birkhäuser Verlag Basel, 1996 Apoptosis nationallicence protein tyrosine kinase nationallicence protein kinase C nationallicence cell cycle nationallicence PI3-kinase nationallicence DNA-PK nationallicence Lavin M. Cancer Research Unit, Queensland Institute of Medical Research, The Bancroft Centre, Herston, PO Royal Brisbane Hospital, 4029, Brisbane, (Australia) aut Watters D. Cancer Research Unit, Queensland Institute of Medical Research, The Bancroft Centre, Herston, PO Royal Brisbane Hospital, 4029, Brisbane, (Australia) aut Song Q. Cancer Research Unit, Queensland Institute of Medical Research, The Bancroft Centre, Herston, PO Royal Brisbane Hospital, 4029, Brisbane, (Australia) aut Experientia Birkhäuser-Verlag 52/10-11(1996-10-01), 979-994 0014-4754 52:10-11<979 1996 52 18 https://doi.org/10.1007/BF01920107 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01920107 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lavin M. Cancer Research Unit, Queensland Institute of Medical Research, The Bancroft Centre, Herston, PO Royal Brisbane Hospital, 4029, Brisbane, (Australia) aut NATIONALLICENCE 700 1- Watters D. Cancer Research Unit, Queensland Institute of Medical Research, The Bancroft Centre, Herston, PO Royal Brisbane Hospital, 4029, Brisbane, (Australia) aut NATIONALLICENCE 700 1- Song Q. Cancer Research Unit, Queensland Institute of Medical Research, The Bancroft Centre, Herston, PO Royal Brisbane Hospital, 4029, Brisbane, (Australia) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/10-11(1996-10-01), 979-994 0014-4754 52:10-11<979 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer