caa a22 4500 477084508 CHVBK 20180405111500.0 cr unu---uuuuu 170330e19961001xx s 000 0 eng 10.1007/BF01920106 doi (NATIONALLICENCE)springer-10.1007/BF01920106 Proteases in apoptosis [Elektronische Daten] [B. Zhivotovsky, D. Burgess, S. Orrenius] The interleukin-1 β-converting enzyme (ICE)-like family proteases have recently been identified as key enzymes in apoptotic cell death. Among these proteases one can identify specific activities which may be involved in cytokine production or in resident protein cleavage. Several factors influence the constitutive apoptotic mechanism and may provide insight into the role of protease(s) in apoptosis. Although it appears that ICE family members play a most important role in promoting apoptotic cell death, evidence has been advanced that other proteases are also involved in sequential or parallel steps of apoptosis. Activation of a particular protease can lead to processing molecules either of the same or different proteases, leading to an activation of a protease cascade. Here we attempt to summarize the current thinking concerning these proteases and their involvement in apoptosis. Birkhäuser Verlag Basel, 1996 Apoptosis nationallicence proteases nationallicence ICE-like proteases nationallicence protein substrates nationallicence Zhivotovsky B. Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Box 210, S-171 77, Stockholm, (Sweden) aut Burgess D. Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Box 210, S-171 77, Stockholm, (Sweden) aut Orrenius S. Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Box 210, S-171 77, Stockholm, (Sweden) aut Experientia Birkhäuser-Verlag 52/10-11(1996-10-01), 968-978 0014-4754 52:10-11<968 1996 52 18 https://doi.org/10.1007/BF01920106 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01920106 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhivotovsky B. Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Box 210, S-171 77, Stockholm, (Sweden) aut NATIONALLICENCE 700 1- Burgess D. Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Box 210, S-171 77, Stockholm, (Sweden) aut NATIONALLICENCE 700 1- Orrenius S. Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Box 210, S-171 77, Stockholm, (Sweden) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/10-11(1996-10-01), 968-978 0014-4754 52:10-11<968 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer