caa a22 4500 477084524 CHVBK 20180405111500.0 cr unu---uuuuu 170330e19961001xx s 000 0 eng 10.1007/BF01920110 doi (NATIONALLICENCE)springer-10.1007/BF01920110 Importance of the Bcl-2 family in cell death regulation [Elektronische Daten] [T. McDonnell, A. Beham, M. Sarkiss, M. Andersen, P. Lo] Bcl-2 was first identified as a novel transcript associated with the t(14;18) chromosomal breakpoint which occurs in most follicular lymphomas. The deregulated expression of bcl-2 was found to contribute to multistep neoplasia through the suppression of cell death, or apoptosis, in transgenic mouse models. Bcl-2 was subsequently shown to be normally expressed in a variety of tissues and to significantly inhibit the induction of apoptosis in many experimental systems. Bcl-2 is now known to be structurally similar to other proteins, in particular within the domains referred to as BH1 and BH2. This multigene family of cell death regulators includes members which enhance rates of apoptosis, including bcl-xs and bax, and those which inhibit apoptosis, including MCL-1 and bcl-xl. Members of the bcl-2 family physically interact with other proteins, including other family members and these interactions appear to modulate their function. The mechanism(s) by which bcl-2 family members regulate cell death remain in large part unknown, although recent evidence suggests that bcl-2 may interfere with cellular signalling events involved in apoptosis induction. Birkhäuser Verlag Basel, 1996 Bcl-2 nationallicence bax nationallicence bcl-x nationallicence apoptosis nationallicence cell death nationallicence McDonnell T. Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 89, 77030, Houston, Texas, USA aut Beham A. Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 89, 77030, Houston, Texas, USA aut Sarkiss M. Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 89, 77030, Houston, Texas, USA aut Andersen M. Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 89, 77030, Houston, Texas, USA aut Lo P. Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 89, 77030, Houston, Texas, USA aut Experientia Birkhäuser-Verlag 52/10-11(1996-10-01), 1008-1017 0014-4754 52:10-11<1008 1996 52 18 https://doi.org/10.1007/BF01920110 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01920110 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McDonnell T. Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 89, 77030, Houston, Texas, USA aut NATIONALLICENCE 700 1- Beham A. Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 89, 77030, Houston, Texas, USA aut NATIONALLICENCE 700 1- Sarkiss M. Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 89, 77030, Houston, Texas, USA aut NATIONALLICENCE 700 1- Andersen M. Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 89, 77030, Houston, Texas, USA aut NATIONALLICENCE 700 1- Lo P. Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 89, 77030, Houston, Texas, USA aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/10-11(1996-10-01), 1008-1017 0014-4754 52:10-11<1008 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer