caa a22 4500 477084540 CHVBK 20180405111500.0 cr unu---uuuuu 170330e19961001xx s 000 0 eng 10.1007/BF01920108 doi (NATIONALLICENCE)springer-10.1007/BF01920108 dNTP pools imbalance as a signal to initiate apoptosis [Elektronische Daten] [F. Oliver, M. Collins, A. López-Rivas] Fidelity in DNA synthesis and repair is largely dependent on a balanced supply of deoxynucleotide triphosphate (dNTP) pools. Results from different groups have shown that alterations in dNTP supply result in DNA fragmentation and cell death with characteristics of apoptosis. We have recently shown that in apoptosis driven by deprivation of interleukin-3 (IL-3) in a murine hemopoietic cell line, there is a rapid imbalance in the availability of dNTP that precedes DNA fragmentation. In these cells, dNTP pool balance is closely coupled to the function of the salvage pathway of dNTP synthesis. Apoptosis, induced by treatment of these cells with drugs that inhibit the de novo dNTP synthesis, is prevented when dNTP precursors are supplied through the salvage pathway. IL-3 regulates thymidine kinase activity, suggesting that alterations in dNTP metabolism after IL-3 deprivation could be a relevant event in the commitment of hemopoietic cells to apoptosis. Birkhäuser Verlag Basel, 1996 Apoptosis nationallicence dNTP metabolism nationallicence thymidine kinase nationallicence interleukin-3 nationallicence blc-2 nationallicence hemopoietic cells nationallicence Oliver F. Instituto de Parasitología y Biomedicina, C.S.I.C., c/ Ventanilla 11, E-18001, Granada, (Spain) aut Collins M. Institute of Cancer Research, Fulham Rood, SW3 6JB, London, (UK) aut López-Rivas A. Instituto de Parasitología y Biomedicina, C.S.I.C., c/ Ventanilla 11, E-18001, Granada, (Spain) aut Experientia Birkhäuser-Verlag 52/10-11(1996-10-01), 995-1000 0014-4754 52:10-11<995 1996 52 18 https://doi.org/10.1007/BF01920108 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01920108 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Oliver F. Instituto de Parasitología y Biomedicina, C.S.I.C., c/ Ventanilla 11, E-18001, Granada, (Spain) aut NATIONALLICENCE 700 1- Collins M. Institute of Cancer Research, Fulham Rood, SW3 6JB, London, (UK) aut NATIONALLICENCE 700 1- López-Rivas A. Instituto de Parasitología y Biomedicina, C.S.I.C., c/ Ventanilla 11, E-18001, Granada, (Spain) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/10-11(1996-10-01), 995-1000 0014-4754 52:10-11<995 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer