caa a22 4500 477084559 CHVBK 20180405111500.0 cr unu---uuuuu 170330e19961001xx s 000 0 eng 10.1007/BF01920104 doi (NATIONALLICENCE)springer-10.1007/BF01920104 Cellular catabolism in apoptosis: DNA degradation and endonuclease activation [Elektronische Daten] [J. Montague, J. Cidlowski] Recent research has focused on identifying the biochemical events associated with the apoptotic process. These include specific degradation of the chromatin which was described by Wyllie in 1980 [1], with the report of the appearance of discretely sized DNA fragments from apoptotic rat thymocytes. The fragments corresponded in size to strands of DNA that were cleaved at internucleosomal regions and create a ‘ladder patterns' when electrophoresed on an agarose gel. Because of its near universality, internucleosomal DNA degradation is considered a diagnostic hallmark of cells undergoing apoptosis. It is of great interest to identify the enzymes involved, and some of the candidates will be discussed. Birkhäuser Verlag Basel, 1996 Apoptosis nationallicence cyclophilin nationallicence DNA degradation nationallicence NUC18 nationallicence endonuclease nationallicence Montague J. National Institute of Environmental Health Science, 111 Alexander Drive, P.O. Box 122 33, 27709, Research Triangle Park, North Carolina, USA aut Cidlowski J. National Institute of Environmental Health Science, 111 Alexander Drive, P.O. Box 122 33, 27709, Research Triangle Park, North Carolina, USA aut Experientia Birkhäuser-Verlag 52/10-11(1996-10-01), 957-962 0014-4754 52:10-11<957 1996 52 18 https://doi.org/10.1007/BF01920104 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01920104 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Montague J. National Institute of Environmental Health Science, 111 Alexander Drive, P.O. Box 122 33, 27709, Research Triangle Park, North Carolina, USA aut NATIONALLICENCE 700 1- Cidlowski J. National Institute of Environmental Health Science, 111 Alexander Drive, P.O. Box 122 33, 27709, Research Triangle Park, North Carolina, USA aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/10-11(1996-10-01), 957-962 0014-4754 52:10-11<957 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer