caa a22 4500 477084567 CHVBK 20180405111500.0 cr unu---uuuuu 170330e19961001xx s 000 0 eng 10.1007/BF01920105 doi (NATIONALLICENCE)springer-10.1007/BF01920105 Divergence towards a dead end? Cleavage of the divergent domains of ribosomal RNA in apoptosis [Elektronische Daten] [G. Houge, S. Døskeland] In several cases of apoptotic death the large ribosomal subunit 28S rRNA is specifically cleaved. The cleavages appear at specific sites within those domains of the rRNA molecule that have shown exceptional high divergence in evolution (D domains). The cleavages accompany rather than precede apoptosis, and there is a positive, but not complete, correlation between rRNA cleavage and internucleosomal DNa fragmentation. Most cell types studied so far show two alternative cleavage pathways that are mutually exclusive. Cleavage can either start in the D8 domain with secondary cuts within a subdomain of D2 (D2c), or in the D2 domain with subsequent excision of the D2c subdomain. The latter pathway is of particular interest since D2 (unlike D8) is normally inaccessible for RNase attack. That apoptosis specifically affects the ribosomal divergent domains suggests that these domains, which make up roughly 25% of total cellular RNA, might have evolved to serve functions related to apoptosis. Future studies will be directed to test the hypothesis that rRNA fragmentation may be part of an apoptotic program directed against the elimination of illegitimate (viral?) polynucleotides. Birkhäuser Verlag Basel, 1996 Ribosome nationallicence divergent domains nationallicence apoptosis nationallicence rRNA cleavage nationallicence D2 nationallicence D8 nationallicence Houge G. Department of Anatomy and Cell Biology, University of Bergen, Årstadveien 19, N-5009, Bergen, (Norway) aut Døskeland S. Department of Anatomy and Cell Biology, University of Bergen, Årstadveien 19, N-5009, Bergen, (Norway) aut Experientia Birkhäuser-Verlag 52/10-11(1996-10-01), 963-967 0014-4754 52:10-11<963 1996 52 18 https://doi.org/10.1007/BF01920105 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01920105 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Houge G. Department of Anatomy and Cell Biology, University of Bergen, Årstadveien 19, N-5009, Bergen, (Norway) aut NATIONALLICENCE 700 1- Døskeland S. Department of Anatomy and Cell Biology, University of Bergen, Årstadveien 19, N-5009, Bergen, (Norway) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/10-11(1996-10-01), 963-967 0014-4754 52:10-11<963 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer