caa a22 4500 477084575 CHVBK 20180405111500.0 cr unu---uuuuu 170330e19961001xx s 000 0 eng 10.1007/BF01920109 doi (NATIONALLICENCE)springer-10.1007/BF01920109 Yonish-Rouach Elisheva Laboratoire de Cancérogenèse Moléculaire, UMR 217, DRR, SDV, CEA, F-92265, Fontenay aux-Roses Cedex, (France) aut The p53 tumour suppressor gene: a mediator of a G1 growth arrest and of apoptosis [Elektronische Daten] [Elisheva Yonish-Rouach] The tumour suppressor gene p53 plays a major role in the protection of cells from DNA damage. Activation of the protein in response to irradiation or genotoxic agents, and possibly by other signals, results in growth arrest at the G1 phase of the cell cycle or in apoptosis. While it has been shown that the ability of p53 to function as a sequence-specific transcriptional activator is necessary for the induction of growth arrest, the mechanism of p53-mediated apoptosis is not yet clear. It appears that under some conditions activation of the G1 checkpoint will prevent apoptosis, but the cellular environment may alter the result of p53 activation towards cell death. p53 may also directly induce apoptosis through several pathways, which may be transcriptionally dependent or independent. The outcome — a G1 arrest or apoptosis — will depend on a complex network of regulatory signals. Birkhäuser Verlag Basel, 1996 p53 nationallicence G1 arrest nationallicence apoptosis nationallicence tumour suppression nationallicence Experientia Birkhäuser-Verlag 52/10-11(1996-10-01), 1001-1007 0014-4754 52:10-11<1001 1996 52 18 https://doi.org/10.1007/BF01920109 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01920109 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Yonish-Rouach Elisheva Laboratoire de Cancérogenèse Moléculaire, UMR 217, DRR, SDV, CEA, F-92265, Fontenay aux-Roses Cedex, (France) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/10-11(1996-10-01), 1001-1007 0014-4754 52:10-11<1001 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer