caa a22 4500 477084796 CHVBK 20180405111500.0 cr unu---uuuuu 170330e19960201xx s 000 0 eng 10.1007/BF00435979 doi (NATIONALLICENCE)springer-10.1007/BF00435979 The development and psychometric validation of a brain cancer quality-of-life questionnaire for use in combination with general cancer-specific questionnaires [Elektronische Daten] [D. Osoba, N. Aaronson, M. Muller, K. Sneeuw, M. Hsu, W. Yung, M. Brada, E. Newlands] A self-report questionnaire module consisting of 24 items, comprising 5 scales and 7 single items, has been developed for measuring health-related quality of life in patients with brain cancer. Module development proceeded through several stages, including a listing of patient, family and health care professional concerns, the writing of items, field testing in 105 patients with brain cancer and subsequent item reduction and scale construction after multitrait scaling analysis and assessment of internal consistency (Cronbach's coefficient α). The final version of the module exhibits reasonable test-retest stability over a period of one week. Differences in the responses between patients with recently-diagnosed and recurrent cancer and between patients with a Karnofsky Performance Score (KPS) of 50-70 and 80-100 were in the expected direction, indicating that the module of questions is responsive to differing conditions. Patients with either mental confusion, motor deficit or dysphasia indicated problems in several domains and single items as compared to patients without these neurological deficits. Thus, differences in the responses to the items in the brain cancer module appear to reflect differences in neurological status. In adclition, deteriorating neurological status was accompanied by a marked increase in emotional distress, future uncertainty and motor dysfunction. A comparison of the responses in the module with the KPS and with a modified Barthel Activities of Daily Living Index (BADLI) shows moderate correlations, primarily with scales and items that pertain to motor dysfunction, while other scales (such as emotional distress, visual disorder and communication deficit) and most single items are not associated with the KPS or BADLI. Since the emotional distress scale of the module was found to be highly correlated with the emotional function scale of the EORTC QLQ-C30, it could be omitted when the module is used in combination with the QLQ-C30. This would reduce the module to a total of 20 items with four scales and seven single items. The intention is to combine this module of questions with other core or general quality-of-life questionnaires when studying patients with brain cancer in clinical trials. Rapid Science Publishers, 1996 Brain cancer nationallicence brain cancer module nationallicence known groups comparisons nationallicence quality of life nationallicence scale reliability nationallicence Osoba D. British Columbia Cancer Agency, Vancouver, British Columbia, Canada aut Aaronson N. Netherlands Cancer Institute, Amsterdam, The Netherlands aut Muller M. Netherlands Cancer Institute, Amsterdam, The Netherlands aut Sneeuw K. Netherlands Cancer Institute, Amsterdam, The Netherlands aut Hsu M. Integrated Therapeutics Group, Inc., a subsidiary of Schering-Plough, Kenilworth, New Jersey, USA aut Yung W. MD Anderson Cancer Center, Houston, Texas, USA aut Brada M. Royal Marsden Hospital, Surrey, UK aut Newlands E. Charing Cross Hospital, London, UK aut Quality of Life Research Kluwer Academic Publishers 5/1(1996-02-01), 139-150 0962-9343 5:1<139 1996 5 11136 https://doi.org/10.1007/BF00435979 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00435979 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Osoba D. British Columbia Cancer Agency, Vancouver, British Columbia, Canada aut NATIONALLICENCE 700 1- Aaronson N. Netherlands Cancer Institute, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Muller M. Netherlands Cancer Institute, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Sneeuw K. Netherlands Cancer Institute, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Hsu M. Integrated Therapeutics Group, Inc., a subsidiary of Schering-Plough, Kenilworth, New Jersey, USA aut NATIONALLICENCE 700 1- Yung W. MD Anderson Cancer Center, Houston, Texas, USA aut NATIONALLICENCE 700 1- Brada M. Royal Marsden Hospital, Surrey, UK aut NATIONALLICENCE 700 1- Newlands E. Charing Cross Hospital, London, UK aut NATIONALLICENCE 773 0- Quality of Life Research Kluwer Academic Publishers 5/1(1996-02-01), 139-150 0962-9343 5:1<139 1996 5 11136 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer