caa a22 4500 477084877 CHVBK 20180405111501.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF00439228 doi (NATIONALLICENCE)springer-10.1007/BF00439228 Construction and validation of a quality of life questionnaire in Chronic Lower Limb Venous Insufficiency (CIVIQ) [Elektronische Daten] [R. Launois, J. Reboul-Marty, B. Henry] Quality of life may be considerably reduced in patients who are suffering from chronic lower limb venous insufficiency, although existing generic quality of life instruments (NHP, SF-36 or SIP) cannot completely identify their specific complaints. The Chronic Venous Insufficiency Questionnaire (CIVIQ) has been developed by iterative process. First, a pilot group of 20 patients was used to identify a number of important features of quality of life affected by venous insufficiency, other than physical symptoms of discomfort. A second study involving 2,001 subjects was used to reduce the number of items. Subjects were asked to score both the severity of their problems and the importance they attributed to each problem on a 5-point Likert scale. The importance items found in patients with venous insufficiency were subjected to factorial analyses (PCA, PAF). The final version is a 20-item self-administered questionnaire which explores four dimensions: psychological, physical and social functioning and pain. Internal consistency of the questionnaire was validated for each dimension (Cronbach's alpha > 0.820 for three out of four factors). Reproducibility was confirmed in a 60 patient test-retest study. Pearson's correlation coefficients for both the four dimension subscales and for the global score at 2-week intervals were greater than 0.940. Finally, the questionnaire was tested in a randomized clinical trial of 934 patients in order to assess responsiveness and the convergent validity of the instrument, together with the patient's own quality of life. This study demonstrated that convergence was valid: Pearson's correlation coefficients between clinical score differences and quality of life score differences were small (from 0.199-0.564) but were statistically different from 0 (p<0.001). Standardized response mean (SRM) and effect size (ES) were calculated to assess sensitivity to change. SRM and ES both demonstrated considerble responsiveness to change (>0.80). Reliability, face, content, construct validity and responsiveness were also determined for this specific quality of life questionnaire relating to venous insufficiency. Results suggest that this questionnaire may be used with confidence to assess quality of life in clinical trials on chronic venous insufficiency. Rapid Science Publishers, 1996 Lower limb venous insufficiency nationallicence quality of life nationallicence questionnaire nationallicence Launois R. Départment de Santé Publique, Faculté de Médecine Léonard De Vinci, Université de Paris, France aut Reboul-Marty J. Départment de Santé Publique, Faculté de Médecine Léonard De Vinci, Université de Paris, France aut Henry B. Analyses et Recherches sur en Economie de la Santé, (ARCOS), 31 rue Ernest Renan, 92130, Issy les Moulineaux, France aut Quality of Life Research Kluwer Academic Publishers 5/6(1996-12-01), 539-554 0962-9343 5:6<539 1996 5 11136 https://doi.org/10.1007/BF00439228 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00439228 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Launois R. Départment de Santé Publique, Faculté de Médecine Léonard De Vinci, Université de Paris, France aut NATIONALLICENCE 700 1- Reboul-Marty J. Départment de Santé Publique, Faculté de Médecine Léonard De Vinci, Université de Paris, France aut NATIONALLICENCE 700 1- Henry B. Analyses et Recherches sur en Economie de la Santé, (ARCOS), 31 rue Ernest Renan, 92130, Issy les Moulineaux, France aut NATIONALLICENCE 773 0- Quality of Life Research Kluwer Academic Publishers 5/6(1996-12-01), 539-554 0962-9343 5:6<539 1996 5 11136 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer