caa a22 4500 477084958 CHVBK 20180405111501.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/BF00433922 doi (NATIONALLICENCE)springer-10.1007/BF00433922 Criterion-based validation of the EORTC QLQ-C36 in advanced melanoma: The CIPS questionnaire and proxy raters [Elektronische Daten] [V. Sigurdardóttir, Y. Brandberg, M. Sullivan] An extensive quality of life (QOL) investigation of the effects of chemotherapy in patients with generalized malignant melanoma included a validation study of involved questionnaires. The QOL domains of the three basic quality of life questionnaires, the EORTC QLQ-C36 (European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire), a study-specific malignant melanoma (MM) module and the Hospital Anxiety and Depression (HAD) scale vs. the Cancer Inventory of Problem Situations (CIPS) were validated by correlation analyses. The value of using attending nurses and/or next of kin to assess the patients' situation was also examined. Functional and symptom scales of the C36 and the subscales of the HAD showed appropriate convergent and discriminant validity when compared with the CIPS. The subscales of the MM module had less clear relationships, probably due to lack of accordance in the CIPS. Assessments of attending nurses revealed very low correlations with the patients' measures. They under-estimated significantly series of specific symptoms and overestimated nausea and the overall quality of life of the patients. However, assessments of close relatives, mostly spouses, showed moderate to high correlations and no significant difference. These results further strengthen the overall validity of the modular approach of the EORTC QLQ technique. In this context of active chemotherapy in patients with advanced cancer disease, relatives seem to be better surrogates than the attending nurses in assessing the patients' quality of life. Rapid Science Publishers, 1996 Advanced malignant melanoma nationallicence CIPS nationallicence EORTC QLQ-C36 nationallicence HAD scale nationallicence proxy raters nationallicence quality of life nationallicence study-specific melanoma module nationallicence validation nationallicence Sigurdardóttir V. The Psychosocial Unit, Department of General Oncology, Karolinska Hospital, Stockholm, Sweden aut Brandberg Y. The Psychosocial Unit, Department of General Oncology, Karolinska Hospital, Stockholm, Sweden aut Sullivan M. Health Care Research Unit, Department of Medicine, University of Göteborg, Sweden aut Quality of Life Research Kluwer Academic Publishers 5/3(1996-06-01), 375-386 0962-9343 5:3<375 1996 5 11136 https://doi.org/10.1007/BF00433922 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00433922 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sigurdardóttir V. The Psychosocial Unit, Department of General Oncology, Karolinska Hospital, Stockholm, Sweden aut NATIONALLICENCE 700 1- Brandberg Y. The Psychosocial Unit, Department of General Oncology, Karolinska Hospital, Stockholm, Sweden aut NATIONALLICENCE 700 1- Sullivan M. Health Care Research Unit, Department of Medicine, University of Göteborg, Sweden aut NATIONALLICENCE 773 0- Quality of Life Research Kluwer Academic Publishers 5/3(1996-06-01), 375-386 0962-9343 5:3<375 1996 5 11136 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer