caa a22 4500 477085105 CHVBK 20180405111501.0 cr unu---uuuuu 170330e19961001xx s 000 0 eng 10.1007/BF00540020 doi (NATIONALLICENCE)springer-10.1007/BF00540020 Evaluating health-related quality of life in patients with facial acne: development of a self-administered questionnaire for clinical trials [Elektronische Daten] [C. Girman, S. Hartmaier, D. Thiboutot, J. Johnson, B. Barber, C. DeMuro-Mercon, J. Waldstreicher] Although psycholosocial aspects of skin diseases are well known, disease-specific questionnaires validated for use in clinical trials are not available to assess the impact of facial acne on health-related quality of life or to evaluate therapeutic change. Development of such an instrument was undertaken and included item generation, reduction and pilottesting phases. By interviewing acne subjects and dermatologists and literature review, 168 possible items were identified. Next, 165 acne subjects identified which items affected them and rated importance on a 5-point scale. Reduction to a brief questionnaire was performed by evaluating patient-perceived importance and factor analysis; four domains were identified (self-perception, roleemotional, role-social, acne symptoms). After pilot-testing for comprehension in acne subjects, further revisions were made to improve clarity and applicability. The resulting instrument takes 10 minutes to complete, and consists of 24 questions assessing how acne affected certain aspects of patients' lives during the past week on a 7-point scale. Thus, an instrument with excellent content validity was developed to assess health-related quality of life in patients with facial acne, and is comprised of statistically meaningful items of importance to patients. Other measurement characteristics are being assessed in a recently initiated study to evaluate test-retest reliability and responsiveness to therapy. Rapid Science Publishers, 1996 Acne vulgaris nationallicence psychosocial nationallicence quality of life nationallicence questionnaire nationallicence Girman C. Department of Epidemiology, Merck Research Laboratories, USA aut Hartmaier S. Hartmaier Consulting, USA aut Thiboutot D. Division of Dermatology at the Pennsylvania State University College of Medicine, USA aut Johnson J. Department of Dermatology at the Hospital of the University of Pennsylvania, USA aut Barber B. Department of Health Economic Statistics, Merck Research Laboratories, USA aut DeMuro-Mercon C. Department of Epidemiology, Merck Research Laboratories, USA aut Waldstreicher J. Department of Clinical Research Endocrinology and Metabolism, Merck Research Laboratories, USA aut Quality of Life Research Kluwer Academic Publishers 5/5(1996-10-01), 481-490 0962-9343 5:5<481 1996 5 11136 https://doi.org/10.1007/BF00540020 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00540020 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Girman C. Department of Epidemiology, Merck Research Laboratories, USA aut NATIONALLICENCE 700 1- Hartmaier S. Hartmaier Consulting, USA aut NATIONALLICENCE 700 1- Thiboutot D. Division of Dermatology at the Pennsylvania State University College of Medicine, USA aut NATIONALLICENCE 700 1- Johnson J. Department of Dermatology at the Hospital of the University of Pennsylvania, USA aut NATIONALLICENCE 700 1- Barber B. Department of Health Economic Statistics, Merck Research Laboratories, USA aut NATIONALLICENCE 700 1- DeMuro-Mercon C. Department of Epidemiology, Merck Research Laboratories, USA aut NATIONALLICENCE 700 1- Waldstreicher J. Department of Clinical Research Endocrinology and Metabolism, Merck Research Laboratories, USA aut NATIONALLICENCE 773 0- Quality of Life Research Kluwer Academic Publishers 5/5(1996-10-01), 481-490 0962-9343 5:5<481 1996 5 11136 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer