caa a22 4500 477086667 CHVBK 20180405111505.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/BF00171140 doi (NATIONALLICENCE)springer-10.1007/BF00171140 Kumagami H. Department of Otolaryngology, School of Medicine, Nagasaki University, 7-I Sakamoto 1-Chome, 852, Nagasaki, Japan aut Detection of viral antigen in the endolymphatic sac [Elektronische Daten] [H. Kumagami] A study was devised to determine whether or not any immune defense mechanism is present when a virus invades the human endolymphatic sac (ES). The ES was removed from 14 fresh autopsy cases having no known premortem diseases in the middle and inner ears. Specimens were then examined for viral antigens including herpes simplex (HSV) type 1 and 2, mumps and cytomegalovirus using immunohistochemical methods. DNA examination by in situ hybridization was also performed for HSV HSV antigen and DNA were observed in 9 of the 14 cases studied. These findings suggest that the virus invades the ES but is impeded by an immune defense mechanism under normal conditions. Since disease may alter host defenses, further studies are warranted to study the relationship between HSV and patients with Meniere's disease. Springer-Verlag, 1996 Endolymphatic sac nationallicence Immune mechanisms nationallicence viral antigen nationallicence Meniere's disease nationallicence European Archives of Oto-Rhino-Laryngology Springer-Verlag 253/4-5(1996-05-01), 264-267 0937-4477 253:4-5<264 1996 253 405 https://doi.org/10.1007/BF00171140 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00171140 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Kumagami H. Department of Otolaryngology, School of Medicine, Nagasaki University, 7-I Sakamoto 1-Chome, 852, Nagasaki, Japan aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer-Verlag 253/4-5(1996-05-01), 264-267 0937-4477 253:4-5<264 1996 253 405 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer