caa a22 4500 477086764 CHVBK 20180405111505.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/BF00171129 doi (NATIONALLICENCE)springer-10.1007/BF00171129 A comparison of morphological effects on the rabbit nasal and sinus mucosa after surgical denervation and topical capsaicin application [Elektronische Daten] [T. Norlander, W. Bolger, P. Stierna, R. Uddman, B. Carlsöö] In order to study morphological effects on the nasal and sinus mucosa, New Zealand White rabbits underwent either unselective, regional sectioning of sensory and parasympathetic nerve branches or topical treatment of the mucosa with capsaicin. Ten days after treatment, mucosal specimens were analyzed by light and electron microscopy. Immunohistochemistry was used to evaluate neuropeptides present, in particular substance P, calcitonin gene-related peptide, vasoactive intestinal peptide and neuropeptide Y. In surgically denervated rabbits, mucosal glands were found to be enlarged and contained an increased number of zymogen granules having a bipartite substructure. Topical capsaicin application caused localized epithelial changes in the sinus mucosa and maxilloturbinal region of the nose, including clotting of cilia and an increased number of goblet cells. Reduced amounts of all neuropeptides investigated were found in the surgically denervated animals, while topical capsaicin treatment had only marginal effects on the mucosal neuropeptide content. The morphological changes observed after surgical denervation suggest an imbalance between neural stimulation and secretory capacity of the mucosal glands. These findings could explain the difference in clinical effect noted between sectioning of the vidian nerve and topical treatment with capsaicin in patients with perennial rhinitis. Springer-Verlag, 1996 Nasal neuropeptides nationallicence Perennial rhinitis nationallicence Mucosal glands nationallicence Immunofluorescence nationallicence Electron microscopy nationallicence Norlander T. Department of Oto-Rhino-Laryngology, Karolinska Institute, Huddinge Hospital, Huddinge, Sweden aut Bolger W. Department of Surgery, Uniformed Services University of Health Sciences, Bethesda, Maryland, USA aut Stierna P. Department of Oto-Rhino-Laryngology, Karolinska Institute, Huddinge Hospital, Huddinge, Sweden aut Uddman R. Department of Oto-Rhino-Laryngology, Malmö General Hospital, Lund University, Lund, Sweden aut Carlsöö B. Department of Oto-Rhino-Laryngology, Karolinska Institute, Huddinge Hospital, Huddinge, Sweden aut European Archives of Oto-Rhino-Laryngology Springer-Verlag 253/4-5(1996-05-01), 205-213 0937-4477 253:4-5<205 1996 253 405 https://doi.org/10.1007/BF00171129 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00171129 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Norlander T. Department of Oto-Rhino-Laryngology, Karolinska Institute, Huddinge Hospital, Huddinge, Sweden aut NATIONALLICENCE 700 1- Bolger W. Department of Surgery, Uniformed Services University of Health Sciences, Bethesda, Maryland, USA aut NATIONALLICENCE 700 1- Stierna P. Department of Oto-Rhino-Laryngology, Karolinska Institute, Huddinge Hospital, Huddinge, Sweden aut NATIONALLICENCE 700 1- Uddman R. Department of Oto-Rhino-Laryngology, Malmö General Hospital, Lund University, Lund, Sweden aut NATIONALLICENCE 700 1- Carlsöö B. Department of Oto-Rhino-Laryngology, Karolinska Institute, Huddinge Hospital, Huddinge, Sweden aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer-Verlag 253/4-5(1996-05-01), 205-213 0937-4477 253:4-5<205 1996 253 405 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer