caa a22 4500 477086845 CHVBK 20180405111505.0 cr unu---uuuuu 170330e19960801xx s 000 0 eng 10.1007/BF00178291 doi (NATIONALLICENCE)springer-10.1007/BF00178291 Effect of cisplatin on the negative charge barrier in strial vessels of the guinea pig A transmission electron microscopic study using polyethyleneimine molecules [Elektronische Daten] [M. Suzuki, K. Kaga] The anionic sites on the basement membrane in the cochlea are believed to act as a charge barrier. Using polyethyleneimine (PEI) as a cationic tracer, we examined the effects of cisplatin (CDDP) on anionic sites in the basement membrane in the cochlea. Eight Hartley-strain guinea pigs were separated into control (buffer administration) and CDDP groups. Ultrathin sections of the basal and third turns of the cochlear ducts were examined using a transmission electron microscope. A marked decrease of PEI distribution was noted in the strial vessels of the CDDP group compared to the control group. However, the two groups showed no signigicant differences in PEI particles on the basement membranes in the basilar and Reissner's membranes, or in the basal and third turns. These findings suggest that the charge barrier in the stria vascularis may be easily inured by the administration of CDDP. Springer-Verlag, 1996 Cisplatin nationallicence Basement membrane anionic sites nationallicence Cochlea nationallicence Stria vascularis nationallicence Polyethyleneimine tracer nationallicence Suzuki M. Department of Otolaryngology, Tohsei National Hospital, 762-1, Nagasawa, Shimizu-cho, Sumoh-gun, Shizuoka, Japan aut Kaga K. Department of Otolaryngology, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan aut European Archives of Oto-Rhino-Laryngology Springer-Verlag 253/6(1996-08-01), 351-355 0937-4477 253:6<351 1996 253 405 https://doi.org/10.1007/BF00178291 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00178291 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Suzuki M. Department of Otolaryngology, Tohsei National Hospital, 762-1, Nagasawa, Shimizu-cho, Sumoh-gun, Shizuoka, Japan aut NATIONALLICENCE 700 1- Kaga K. Department of Otolaryngology, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer-Verlag 253/6(1996-08-01), 351-355 0937-4477 253:6<351 1996 253 405 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer