caa a22 4500 477086926 CHVBK 20180405111506.0 cr unu---uuuuu 170330e19960801xx s 000 0 eng 10.1007/BF00178294 doi (NATIONALLICENCE)springer-10.1007/BF00178294 Effects of furosemide on intracochlear oxygen tension in the guinea pig [Elektronische Daten] [J. Liu, X. Zhou, Y. Yuan] The effects of intravenous furosemide on the perilymphatic oxygen tension of the scala tympani (OT) in the guinea pig and the relationship between changes in OT and changes in auditory cortical-evoked reponses were studied, as well as changes in cochlear morphology. Furosemide in dosages of 25 mg/kg and 50 mg/kg caused a sharp decline in OT in addition to elevation of the threshold of auditory cortical-evoked responses. Ischemia of the cochlear stria vascularis was also found but without any damage of hair cells at the light microscopic level. Changes in OT were associated with transient threshold elevations and ischemia of the stria vascularis. Improvements in hearing were directly proportional to the recovery of OT. Springer-Verlag, 1996 Furosemide-induced ototoxicity nationallicence Scala tympani nationallicence Oxygen tension nationallicence Auditory cortical-evoked potentials nationallicence Liu J. Department of Otolaryngology, First Central Hospital, Tianjin Medical University, 300192, Tianjin, China aut Zhou X. Department of Otolaryngology, First Central Hospital, Tianjin Medical University, 300192, Tianjin, China aut Yuan Y. Department of Otolaryngology, First Central Hospital, Tianjin Medical University, 300192, Tianjin, China aut European Archives of Oto-Rhino-Laryngology Springer-Verlag 253/6(1996-08-01), 367-370 0937-4477 253:6<367 1996 253 405 https://doi.org/10.1007/BF00178294 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00178294 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liu J. Department of Otolaryngology, First Central Hospital, Tianjin Medical University, 300192, Tianjin, China aut NATIONALLICENCE 700 1- Zhou X. Department of Otolaryngology, First Central Hospital, Tianjin Medical University, 300192, Tianjin, China aut NATIONALLICENCE 700 1- Yuan Y. Department of Otolaryngology, First Central Hospital, Tianjin Medical University, 300192, Tianjin, China aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer-Verlag 253/6(1996-08-01), 367-370 0937-4477 253:6<367 1996 253 405 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer