caa a22 4500 477087051 CHVBK 20180405111506.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF00168497 doi (NATIONALLICENCE)springer-10.1007/BF00168497 Different effects of noise and salicylate and their interactions on the guinea pig cochlea [Elektronische Daten] [M. Aoyagi, M. Yoshida, K. Makishima] We investigated the effects of noise and salicylate on the guinea pig cochlea by monitoring the acoustic nerve compound action potential (CAP) as well as the 2f1-f2 distortion product in the cochlear microphonics (DP-CM). The alterations of DP-CMs by noise and salicylate revealed an apparent difference, even when the noise-induced and salicylate-induced CAP threshold shifts were equal. This result indicated that noise and salicylate might have an effect on different sites in the cochlea. Combined effects were altered by changing the order in which the two agents were applied. The existing noise-induced damage attenuated the additional ototoxicity of salicylate. In contrast, attenuation did not occur when salicylate administration preceded noise exposure. Considering known effects of noise and/or salicylate altering mechano-electrical transduction (MET) and electro-mechanical transduction of the cochlear outer hair cells, our results seem to suggest that the MET plays a key role in the transduction mechanism in the cochlea. Springer-Verlag, 1996 Noise nationallicence Outer hair cells nationallicence Salicylate toxicity Temporary auditory threshold shifts nationallicence 2f 142 distortion product nationallicence Aoyagi M. Department of Otorhinolaryngology, University of Occupational and Environmental Health, School of Medicine, 807, Yahata-nishiku, Kitakyushu, Japan aut Yoshida M. Department of Otorhinolaryngology, University of Occupational and Environmental Health, School of Medicine, 807, Yahata-nishiku, Kitakyushu, Japan aut Makishima K. Department of Otorhinolaryngology, University of Occupational and Environmental Health, School of Medicine, 807, Yahata-nishiku, Kitakyushu, Japan aut European Archives of Oto-Rhino-Laryngology Springer-Verlag 253/7(1996-09-01), 429-434 0937-4477 253:7<429 1996 253 405 https://doi.org/10.1007/BF00168497 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00168497 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Aoyagi M. Department of Otorhinolaryngology, University of Occupational and Environmental Health, School of Medicine, 807, Yahata-nishiku, Kitakyushu, Japan aut NATIONALLICENCE 700 1- Yoshida M. Department of Otorhinolaryngology, University of Occupational and Environmental Health, School of Medicine, 807, Yahata-nishiku, Kitakyushu, Japan aut NATIONALLICENCE 700 1- Makishima K. Department of Otorhinolaryngology, University of Occupational and Environmental Health, School of Medicine, 807, Yahata-nishiku, Kitakyushu, Japan aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer-Verlag 253/7(1996-09-01), 429-434 0937-4477 253:7<429 1996 253 405 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer