caa a22 4500 477087124 CHVBK 20180405111506.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF00615110 doi (NATIONALLICENCE)springer-10.1007/BF00615110 Time-dependent alterations of 3-fucosyl- N -acetyl-lactosamine (CD15) expression in the endolymphatic sac of adult guinea pigs after glycerol administration [Elektronische Daten] [A. Meyer zum Gottesberge, J. Mai] The present study examined the effect of glycerol administration on 3-fucosyl-N-acetyl-lactosamine (CD15) epitope expression in the endolymphatic sac (ES) of the guinea pig's inner ear. Adult guinea pigs were injected intravenously with glycerol (2 g/kg body wt.). CD15 expression was studied at 80 min up to 5 h after treatment. In untreated animals single cells and cell groups in the ES expressing CD15 epitope intra- and intercellularly were identified by immunohistochemistry to be mainly in the epithelial layer of the rugosal and distal part of the sac. Glycerol administration modulated the expression of CD15 epitope. In the epithelial layer, expression decreased and was nearly depleted after 3 h. After 4 h of glycerol administration, CD15 expression reappeared and reached the comparable level of controls. The numbers of CD15-positive cells in the lumen of the ES increased steadily and arrived at their the highest levels in 2-h specimens. The localization of CD15-epitope expression and its modulation after glycerol administration within the ES implies that this molecule may play a role in re-establishing the sac's normal function. In addition, we speculate that CD15 may be associated with processes of an immune response in the inner ear. Springer-Verlag, 1996 Endolymphatic sac nationallicence Glycoconjugates nationallicence Fluid regulation nationallicence Immune response nationallicence Menière's disease nationallicence Meyer zum Gottesberge A. Research Laboratory, Department of Otorhinolaryngology, Heinrich Heine University, Moorenstrasse 5, D-40225, Dusseldorf, Germany aut Mai J. Department of Neuroanatomy, Heinrich Heine University, Dusseldorf, Germany aut European Archives of Oto-Rhino-Laryngology Springer-Verlag 253/3(1996-01-01), 136-141 0937-4477 253:3<136 1996 253 405 https://doi.org/10.1007/BF00615110 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00615110 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Meyer zum Gottesberge A. Research Laboratory, Department of Otorhinolaryngology, Heinrich Heine University, Moorenstrasse 5, D-40225, Dusseldorf, Germany aut NATIONALLICENCE 700 1- Mai J. Department of Neuroanatomy, Heinrich Heine University, Dusseldorf, Germany aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer-Verlag 253/3(1996-01-01), 136-141 0937-4477 253:3<136 1996 253 405 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer