caa a22 4500 477087248 CHVBK 20180405111507.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF00615109 doi (NATIONALLICENCE)springer-10.1007/BF00615109 Verrucous squamous cell carcinoma of the larynx: diagnostic and therapeutic considerations [Elektronische Daten] [M. Maurizi, G. Cadoni, F. Ottaviani, C. Rabitti, G. Almadori] The clinical findings, histopathology, management and outcome of 31 patients with verrucous squamous cell carcinoma of the larynx (VSCC) are discussed. Laryngeal VSCC is a rare, highly differentiated variant of SCC and has specific morphological features and clinical behavior. A close liaison between the laryngologist and pathologist is needed to formulate a correct diagnosis, because this tumor appears to be malignant clinically and histologically benign. A low-power magnification of multiple large specimens, including the deep margins of the lesion, is required in order to differentiate VSCC from keratosis, verruca vulgaris or SCC with verrucous appearance, and to detect underlying microscopic foci of invasive SCC within or adjacent to a verrucous carcinoma. Long-lasting hoarseness was the most common symptom as the glottic region was the most common site of VSCC. Presumed clinically positive N1 lymph nodes were observed in the necks of 7 patients, but none had metastatic disease on histopathological study. Surgery alone was the most effective form of treatment, as it allowed a good outcome of all treated patients. Surgery plus radiotherapy was associated with an early recurrence and a poor outcome in 2 of 7 patients treated. The generally "benign” behavior of VSCC allows for conservative surgery, with complete endoscopic resection using the carbon dioxide laser representing a more conservative surgical approach. Neck dissection is not indicated due to the non-metastatic behavior of this tumor. Springer-Verlag, 1996 Larynx nationallicence Verrucous squamous cell carcinoma nationallicence Histopathology nationallicence Maurizi M. Institute of Otorhinolaryngology, Universita' Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, I-00168, Rome, Italy aut Cadoni G. Institute of Otorhinolaryngology, Universita' Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, I-00168, Rome, Italy aut Ottaviani F. Institute of Otorhinolaryngology, Universita' Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, I-00168, Rome, Italy aut Rabitti C. Institute of Pathology, Universita' Cattolica del Sacro Cuore, I-00168, Rome, Italy aut Almadori G. Institute of Otorhinolaryngology, Universita' Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, I-00168, Rome, Italy aut European Archives of Oto-Rhino-Laryngology Springer-Verlag 253/3(1996-01-01), 130-135 0937-4477 253:3<130 1996 253 405 https://doi.org/10.1007/BF00615109 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00615109 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maurizi M. Institute of Otorhinolaryngology, Universita' Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, I-00168, Rome, Italy aut NATIONALLICENCE 700 1- Cadoni G. Institute of Otorhinolaryngology, Universita' Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, I-00168, Rome, Italy aut NATIONALLICENCE 700 1- Ottaviani F. Institute of Otorhinolaryngology, Universita' Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, I-00168, Rome, Italy aut NATIONALLICENCE 700 1- Rabitti C. Institute of Pathology, Universita' Cattolica del Sacro Cuore, I-00168, Rome, Italy aut NATIONALLICENCE 700 1- Almadori G. Institute of Otorhinolaryngology, Universita' Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, I-00168, Rome, Italy aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer-Verlag 253/3(1996-01-01), 130-135 0937-4477 253:3<130 1996 253 405 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer