caa a22 4500 477087388 CHVBK 20180405111507.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF00176698 doi (NATIONALLICENCE)springer-10.1007/BF00176698 Effects of Ginkgo biloba extract (EGb 761) on cochlear vasculature in the guinea pig: morphometric measurements and laser Doppler flowmetry [Elektronische Daten] [A. Didier, M. Droy-Lefaix, C. Aurousseau, Y. Cazals] Ginkgo biloba extract (EGb 761) was administered orally for 4 or 6 weeks to healthy adult guinea pigs. Animals were then decapitated under deep ketamine anesthesia. Post-mortem morphometric measurements of cochlear vessels in the spiral lamina revealed a vasodilating effect of the extract in four of ten animals following 6 weeks of treatment. In vivo testing of the effect of 4 or 6 weeks of treatment with EGb 761 was monitored with laser Doppler flowmetry of the cochlear blood flow under pathological conditions. Results demonstrated that EGb 761 partly counteracted sodium salicylate-induced decreases in cochlear blood flow (CBF) and enhanced CBF increases induced by hypoxia. These findings indicate that EGb 761 may help to improve oxygenation in cochleas with compromised blood flow. Springer-Verlag, 1996 Cochlear blood flow nationallicence Hypoxia nationallicence Ototoxicity Laser Doppler flowmetry nationallicence Ginkgo biloba extract nationallicence Didier A. Department of Otolaryngology, Kresge Hearing Research Institute, University of Michigan, 48109-0506, Ann Arbor, MI, USA aut Droy-Lefaix M. Ipsen Institute, F-75781, 16, Paris cedex, France aut Aurousseau C. Laboratoire d'Audiologie Expérimentale, Inserm U 229, Hôpital Pellegrin, F-33076, Bordeaux, France aut Cazals Y. Laboratoire d'Audiologie Expérimentale, Inserm U 229, Hôpital Pellegrin, F-33076, Bordeaux, France aut European Archives of Oto-Rhino-Laryngology Springer-Verlag 253/1-2(1996-01-01), 25-30 0937-4477 253:1-2<25 1996 253 405 https://doi.org/10.1007/BF00176698 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00176698 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Didier A. Department of Otolaryngology, Kresge Hearing Research Institute, University of Michigan, 48109-0506, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Droy-Lefaix M. Ipsen Institute, F-75781, 16, Paris cedex, France aut NATIONALLICENCE 700 1- Aurousseau C. Laboratoire d'Audiologie Expérimentale, Inserm U 229, Hôpital Pellegrin, F-33076, Bordeaux, France aut NATIONALLICENCE 700 1- Cazals Y. Laboratoire d'Audiologie Expérimentale, Inserm U 229, Hôpital Pellegrin, F-33076, Bordeaux, France aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer-Verlag 253/1-2(1996-01-01), 25-30 0937-4477 253:1-2<25 1996 253 405 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer