caa a22 4500 477087493 CHVBK 20180405111507.0 cr unu---uuuuu 170330e19961101xx s 000 0 eng 10.1007/BF00179957 doi (NATIONALLICENCE)springer-10.1007/BF00179957 Effects of amphetamine on human nasal mucosa [Elektronische Daten] [H. Wang, S. Wang, W. Su, J. Wang] The present study was devised to determine the effects of amphetamine on the sympathetic function of human nasal mucosa. A tissue bath method was employed on the vitro preparations of nasal turbinate mucosa from adult patients with nasal allergies or hypertrophic rhinitis. The effects of amphetamine on the contractile response of isolated human nasal mucosal blood vessels were investigated following electrical field stimulation and methoxamine. The results showed that amphetamine inhibited field stimulation and antagonized the effects on mucosal contraction induced by methoxamine. Likewise, the drug increased mucosal basal tension but had local drug toxicity when a 10−4 M solution was used. Amphetamine could potentiate mucosal contraction induced by norepinephrine or epinephrine. The study indicated that amphetamine may increase sympathetic function by potentiating the effect of norepinephrine and that high concentrations of amphetamine may actually antagonize a-adrenoceptors. Springer-Verlag, 1996 Amphetamine nationallicence Sympathetic function nationallicence Nasal mucosa nationallicence Wang H. Department of Otolaryngology, Tri-Service General Hospital, National Defense Medical Center, P.O. Box 90048, Taipei, Taiwan, Republic of China aut Wang S. Department of Otolaryngology, Tri-Service General Hospital, National Defense Medical Center, P.O. Box 90048, Taipei, Taiwan, Republic of China aut Su W. Department of Otolaryngology, Tri-Service General Hospital, National Defense Medical Center, P.O. Box 90048, Taipei, Taiwan, Republic of China aut Wang J. Department of Physiology and Biophysics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China aut European Archives of Oto-Rhino-Laryngology Springer-Verlag 253/8(1996-11-01), 498-500 0937-4477 253:8<498 1996 253 405 https://doi.org/10.1007/BF00179957 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00179957 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang H. Department of Otolaryngology, Tri-Service General Hospital, National Defense Medical Center, P.O. Box 90048, Taipei, Taiwan, Republic of China aut NATIONALLICENCE 700 1- Wang S. Department of Otolaryngology, Tri-Service General Hospital, National Defense Medical Center, P.O. Box 90048, Taipei, Taiwan, Republic of China aut NATIONALLICENCE 700 1- Su W. Department of Otolaryngology, Tri-Service General Hospital, National Defense Medical Center, P.O. Box 90048, Taipei, Taiwan, Republic of China aut NATIONALLICENCE 700 1- Wang J. Department of Physiology and Biophysics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer-Verlag 253/8(1996-11-01), 498-500 0937-4477 253:8<498 1996 253 405 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer