caa a22 4500 477087523 CHVBK 20180405111507.0 cr unu---uuuuu 170330e19961101xx s 000 0 eng 10.1007/BF00179955 doi (NATIONALLICENCE)springer-10.1007/BF00179955 Combined effects of acute lead acetate exposure and tone exposure of the guinea pig cochlea [Elektronische Daten] [S. Hotta, T. Sugisawa, T. Matsui, T. Itoh, K. Yamamura] Lead acetate exposure to humans can induce various disorders of the cranial nerves. Although vertigo and sensorineural deafness have been reported in lead workers, the dose effects of lead acetate on the cochlea and eighth cranial nerve are not well documented. We investigated the effects of lead acetate on the male albino Hartley guinea pig cochlea by measuring cochlear microphonics (CM), whole nerve action potential (AP), endocochlear potential (EP) and K+ ion concentration of the endolymph. Animals were given lead acetate by intraperitoneal injection as 20 mg/week for 4 consecutive weeks. A total dose < 80 mg did not induce electrophysiological changes in the cochlea. However, the AP output voltage (N1) decreased if the 80 mg lead acetate treatment was followed by an 80 dB tone exposure at 6 kHz during 24 h. A change was observed in CM and EP but not K+ ion concentration in the scala media. Springer-Verlag, 1996 Acute lead exposure nationallicence Tone exposure Cochlear microphonics nationallicence Endocochlear potentials nationallicence Scala media ion concentration nationallicence Hotta S. Department of Hygiene, Asahikawa Medical College, 4-5-3-11 Nishikagura, 078, Asahikawa, Japan aut Sugisawa T. Department of Hygiene, Asahikawa Medical College, 4-5-3-11 Nishikagura, 078, Asahikawa, Japan aut Matsui T. Department of Hygiene, Asahikawa Medical College, 4-5-3-11 Nishikagura, 078, Asahikawa, Japan aut Itoh T. Department of Hygiene, Asahikawa Medical College, 4-5-3-11 Nishikagura, 078, Asahikawa, Japan aut Yamamura K. Department of Hygiene, Asahikawa Medical College, 4-5-3-11 Nishikagura, 078, Asahikawa, Japan aut European Archives of Oto-Rhino-Laryngology Springer-Verlag 253/8(1996-11-01), 488-493 0937-4477 253:8<488 1996 253 405 https://doi.org/10.1007/BF00179955 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00179955 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hotta S. Department of Hygiene, Asahikawa Medical College, 4-5-3-11 Nishikagura, 078, Asahikawa, Japan aut NATIONALLICENCE 700 1- Sugisawa T. Department of Hygiene, Asahikawa Medical College, 4-5-3-11 Nishikagura, 078, Asahikawa, Japan aut NATIONALLICENCE 700 1- Matsui T. Department of Hygiene, Asahikawa Medical College, 4-5-3-11 Nishikagura, 078, Asahikawa, Japan aut NATIONALLICENCE 700 1- Itoh T. Department of Hygiene, Asahikawa Medical College, 4-5-3-11 Nishikagura, 078, Asahikawa, Japan aut NATIONALLICENCE 700 1- Yamamura K. Department of Hygiene, Asahikawa Medical College, 4-5-3-11 Nishikagura, 078, Asahikawa, Japan aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer-Verlag 253/8(1996-11-01), 488-493 0937-4477 253:8<488 1996 253 405 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer