caa a22 4500 477089402 CHVBK 20180405111512.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF02265050 doi (NATIONALLICENCE)springer-10.1007/BF02265050 Are proteasomes involved in the formation of the kinetochore? [Elektronische Daten] [N. Paweletz, C. Wójcik, D. Schroeter, E. Finze] Proteasomes catalyse the degradation of proteins responsible for the regulation of mitosis enabling the cell to complete cell division. We have studied the effect of an inhibitor of the chymotrypsin-like activity of the proteasome on the trilaminar structure of the kinetochore in HeLa cells. Whereas a role for the proteasome in the degeneration of the kinetochore was predicted, we found instead that the inhibitor strongly retarded kinetochore development. We observed different ‘developmental' stages of the kinetochore from the fibrous ball of a ‘prekinetochore' to the ‘mature' kinetochore in one cell. The data presented here support the proposition that proteasomes are involved in kinetochore formation. Rapid Science Publishers, 1996 cell cycle regulation nationallicence centromere nationallicence kinetochore nationallicence microtubules nationallicence mitosis nationallicence proteasomes nationallicence Paweletz N. Division 0430, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg aut Wójcik C. Department of Histology and Embryology, Institute of Biostructure, Warsaw Medical Academy, Warsaw, Poland aut Schroeter D. Division 0430, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg aut Finze E. Division 0430, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg aut Chromosome Research Kluwer Academic Publishers 4/6(1996-09-01), 436-442 0967-3849 4:6<436 1996 4 10577 https://doi.org/10.1007/BF02265050 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02265050 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Paweletz N. Division 0430, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg aut NATIONALLICENCE 700 1- Wójcik C. Department of Histology and Embryology, Institute of Biostructure, Warsaw Medical Academy, Warsaw, Poland aut NATIONALLICENCE 700 1- Schroeter D. Division 0430, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg aut NATIONALLICENCE 700 1- Finze E. Division 0430, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg aut NATIONALLICENCE 773 0- Chromosome Research Kluwer Academic Publishers 4/6(1996-09-01), 436-442 0967-3849 4:6<436 1996 4 10577 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer