caa a22 4500 477090222 CHVBK 20180405111514.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF02259706 doi (NATIONALLICENCE)springer-10.1007/BF02259706 Hasenkampf Clare Division of Life Science, University of Toronto-Scarborough Campus, 1265 Military Trail, M1C 1A4, Scarborough, Ontario, Canada aut The synaptonemal complex — the chaperone of crossing over [Elektronische Daten] [Clare Hasenkampf] During meiosis homologous chromosomes pair and exchange homologous chromosome segments. The synaptonemal complex (SC) forms between paired chromosomes. The role of the SC in the process of reciprocal exchange of flanking markers is a matter of debate. I propose a dual pathway for reciprocal exchange of flanking markers (REFM). In the first, SC-independent, path, two ‘half-nodules' and an independent REFM protein combine to form a functional recombination nodule (RN). The RN binds to paired chromosomes and accomplishes reciprocal exchange of flanking markers. In the other, SC-dependent, pathway ‘half-nodules' occur at pairing initiation sites. ‘Half-nodules' move along the SC as it forms. Assisted by an SC-bound REFM protein, ‘half-nodules' combine to form functional RNs. I propose that different organisms rely to different extents on the two pathways, and hence rely to different extents on the SC. Rapid Science Publishers, 1996 crossing over nationallicence recombination nodules nationallicence synaptonemal complex nationallicence Chromosome Research Kluwer Academic Publishers 4/2(1996-03-01), 133-140 0967-3849 4:2<133 1996 4 10577 https://doi.org/10.1007/BF02259706 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02259706 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Hasenkampf Clare Division of Life Science, University of Toronto-Scarborough Campus, 1265 Military Trail, M1C 1A4, Scarborough, Ontario, Canada aut NATIONALLICENCE 773 0- Chromosome Research Kluwer Academic Publishers 4/2(1996-03-01), 133-140 0967-3849 4:2<133 1996 4 10577 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer