caa a22 4500 477094333 CHVBK 20180405111523.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF01771238 doi (NATIONALLICENCE)springer-10.1007/BF01771238 Stable lead isotope profiles in smelter and general urban communities: a comparison of environmental and blood measures [Elektronische Daten] [Brian Gulson, Dino Pisaniello, Anthony McMichael, Karen Mizon, Michael Korsch, Colin Luke, Rosie Ashbolt, David Pederson, Graham Vimpani, Kathryn Mahaffey] High-precision lead isotope ratios and lead concentrations have been compared statistically and graphically in women of child-bearing age (n = 77) from two smelter communities and one general urban community to evaluate the relative contributions to blood lead of tissue lead stores and lead from the contemporaneous environment (soil, floor dust, indoor airborne dust, water, food). Blood lead (PbB) contents were generally low (e.g. <10 μg dL−1). Statistically significant isotopic differences in blood and environmental samples were observed between the three cities although isotopic differences in blood for individual subjects living in close proximity (∼200 m radius) was as large as the differences within a city. No single environmental measure dominated the biological isotope profile and in many cases the low levels of blood lead meant that their isotopic profiles could be easily perturbed by relatively small changes of environmental exposure. Apportioning of sources using lead isotopes is possibly not feasible, nor cost effective, when blood lead levels are <5 μg dL−1. Interpretations based on statistical analyses of city-wide data do not give the same conclusions as when the houses are considered individually. Aggregating data from multiple subjects in a study such as this obscures potentially useful information. Most of the measures employed in this study, and many other similar studies, are markers of only short-to-medium integration of lead exposure. Serial sampling of blood and longer sampling times, especially for household variables, should provide more meaningful information. Chapman & Hall, 1996 Lead nationallicence blood nationallicence environmental samples nationallicence isotopes nationallicence Gulson Brian Minerals Research Laboratory, CSIRO/DEM, 51 Delhi Road, 2113, North Ryde, NSW, Australia aut Pisaniello Dino Department of Community Medicine, University of Adelaide, South Australia aut McMichael Anthony Department of Community Medicine, University of Adelaide, South Australia aut Mizon Karen Minerals Research Laboratory, CSIRO/DEM, 51 Delhi Road, 2113, North Ryde, NSW, Australia aut Korsch Michael Minerals Research Laboratory, CSIRO/DEM, 51 Delhi Road, 2113, North Ryde, NSW, Australia aut Luke Colin Health Commission, Adelaide, South Australia aut Ashbolt Rosie Menzies Centre, University of Tasmania, Hobart, Tasmania, Australia aut Pederson David University of Canberra, ACT, Australia aut Vimpani Graham Child, Family and Adolescent Health, Newcastle, NSW, Australia aut Mahaffey Kathryn National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA aut Environmental Geochemistry and Health Kluwer Academic Publishers 18/4(1996-12-01), 147-163 0269-4042 18:4<147 1996 18 10653 https://doi.org/10.1007/BF01771238 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01771238 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gulson Brian Minerals Research Laboratory, CSIRO/DEM, 51 Delhi Road, 2113, North Ryde, NSW, Australia aut NATIONALLICENCE 700 1- Pisaniello Dino Department of Community Medicine, University of Adelaide, South Australia aut NATIONALLICENCE 700 1- McMichael Anthony Department of Community Medicine, University of Adelaide, South Australia aut NATIONALLICENCE 700 1- Mizon Karen Minerals Research Laboratory, CSIRO/DEM, 51 Delhi Road, 2113, North Ryde, NSW, Australia aut NATIONALLICENCE 700 1- Korsch Michael Minerals Research Laboratory, CSIRO/DEM, 51 Delhi Road, 2113, North Ryde, NSW, Australia aut NATIONALLICENCE 700 1- Luke Colin Health Commission, Adelaide, South Australia aut NATIONALLICENCE 700 1- Ashbolt Rosie Menzies Centre, University of Tasmania, Hobart, Tasmania, Australia aut NATIONALLICENCE 700 1- Pederson David University of Canberra, ACT, Australia aut NATIONALLICENCE 700 1- Vimpani Graham Child, Family and Adolescent Health, Newcastle, NSW, Australia aut NATIONALLICENCE 700 1- Mahaffey Kathryn National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA aut NATIONALLICENCE 773 0- Environmental Geochemistry and Health Kluwer Academic Publishers 18/4(1996-12-01), 147-163 0269-4042 18:4<147 1996 18 10653 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer