caa a22 4500 477095259 CHVBK 20180405111525.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/BF00187929 doi (NATIONALLICENCE)springer-10.1007/BF00187929 Distribution of p75 and trk -neurotrophin receptor proteins in adult human sympathetic ganglia [Elektronische Daten] [O. Garcia-Suarez, F. Naves, M. Del Valle, I. Esteban, E. Bronzetti, E. Vazquez, J. Vega] We investigated the expression of immunoreactivity (IR) for low- (p75) and high-affinity (trk proteins) neurotrophin-receptor proteins in adult human paravertebral-sympathetic ganglion neurons. Mouse monoclonal antibodies against the pan-neurotrophin-receptor p75, and rabbit polyclonal antibodies against specific epitopes of the intracytoplasmic domain on trk neurotrophin-receptor proteins were used in fresh unfixed and formaldehyde-fixed paraffin-embedded sympathetic ganglia. All adult human paravertebral-sympathetic neurons displayed trkA neurotrophin-receptor-like protein IR, 10% express trkC neurotrophin-receptor-like protein IR, 37-44% show p75 IR, and no IR was obtained for trkB neurotrophin-receptor-like protein. The intensity of immunostaining was independent of the neuron size. Labelling of non-neuronal tissues, especially blood-vessel walls, was observed for p75, trkA and trkC neurotrophin-receptor proteins. These results indicate that overlapping exists in the expression of p75 and trk neurotrophin-receptor proteins in adult human paravertebral-sympathetic neurons, and suggest that neurotrophins might act on these neurons. Springer-Verlag, 1996 trk neurotrophin-receptor proteins nationallicence p75 protein nationallicence Paravertebral-sympathetic ganglia nationallicence Human nationallicence Garcia-Suarez O. Departamento de Morfología y Biología Celular, Facultad de Medicina, Universidad de Oviedo, E-33006, Oviedo, Spain aut Naves F. Departamento de Morfología y Biología Celular, Facultad de Medicina, Universidad de Oviedo, E-33006, Oviedo, Spain aut Del Valle M. Departamento de Morfología y Biología Celular, Facultad de Medicina, Universidad de Oviedo, E-33006, Oviedo, Spain aut Esteban I. Departamento de Morfología y Biología Celular, Facultad de Medicina, Universidad de Oviedo, E-33006, Oviedo, Spain aut Bronzetti E. Dipartimento di Scienze Cardiovascolari e Respiratorie, Université "La Sapienza”, I-0161, Roma, Italy aut Vazquez E. Departamento de Bioquimica, Biología Molecular y Fisiología, Facultad de Medicina, Universidad de Valladolid, C.S.I.C., E-47005, Valladolid, Spain aut Vega J. Departamento de Morfología y Biología Celular, Facultad de Medicina, Universidad de Oviedo, E-33006, Oviedo, Spain aut Anatomy and Embryology Springer-Verlag 193/6(1996-06-01), 577-583 0340-2061 193:6<577 1996 193 429 https://doi.org/10.1007/BF00187929 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00187929 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Garcia-Suarez O. Departamento de Morfología y Biología Celular, Facultad de Medicina, Universidad de Oviedo, E-33006, Oviedo, Spain aut NATIONALLICENCE 700 1- Naves F. Departamento de Morfología y Biología Celular, Facultad de Medicina, Universidad de Oviedo, E-33006, Oviedo, Spain aut NATIONALLICENCE 700 1- Del Valle M. Departamento de Morfología y Biología Celular, Facultad de Medicina, Universidad de Oviedo, E-33006, Oviedo, Spain aut NATIONALLICENCE 700 1- Esteban I. Departamento de Morfología y Biología Celular, Facultad de Medicina, Universidad de Oviedo, E-33006, Oviedo, Spain aut NATIONALLICENCE 700 1- Bronzetti E. Dipartimento di Scienze Cardiovascolari e Respiratorie, Université "La Sapienza”, I-0161, Roma, Italy aut NATIONALLICENCE 700 1- Vazquez E. Departamento de Bioquimica, Biología Molecular y Fisiología, Facultad de Medicina, Universidad de Valladolid, C.S.I.C., E-47005, Valladolid, Spain aut NATIONALLICENCE 700 1- Vega J. Departamento de Morfología y Biología Celular, Facultad de Medicina, Universidad de Oviedo, E-33006, Oviedo, Spain aut NATIONALLICENCE 773 0- Anatomy and Embryology Springer-Verlag 193/6(1996-06-01), 577-583 0340-2061 193:6<577 1996 193 429 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer