caa a22 4500 477095674 CHVBK 20180405111526.0 cr unu---uuuuu 170330e19960201xx s 000 0 eng 10.1007/BF00214707 doi (NATIONALLICENCE)springer-10.1007/BF00214707 Long-term structural alterations to endothelial cells in vein-to-artery grafts: a quantitative electron microscopic study [Elektronische Daten] [Marc Tennant, John McGeachie] The intracellular structure of endothelium lining vein-to-artery grafts in rats was analysed, using transmission electron microscopy and morphometry, to determine the ultrastructural adaptations of endothelial cells in this altered vascular environment. Autogenous 4-mm sections of iliolumbar veins were inserted microsurgically into the left common iliac arteries of 16 male Wistar rats. At 3, 6, 26 and 52 weeks the cytoplasmic-vesicular, mitochondrial and rough endoplasmic reticular contents of endothelial cells lining the grafts, the opposite iliac arteries and the remaining ilio-lumbar veins were analysed morphometrically. There was a significant increase in the amount of all these cytoplasmic structures in endothelial cells at 3, 6 and 26 weeks; at 52 weeks there was also a significant increase in the volumes of mitochondria and cytoplasmic vesicles, but not in rough endoplasmic reticulum. It was concluded that the ultrastructure of endothelial cells lining these grafts is changed chronically after graft insertion, and we propose that this may be attributable to altered haemodynamic stresses within the graft. Springer-Verlag, 1996 Endothelium nationallicence Ultrastructure nationallicence Vein graft nationallicence Morphometry nationallicence Tennant Marc The Dental School, The University of Western Australia, 6907, Nedlands, Western Australia, Australia aut McGeachie John Department of Anatomy and Human Biology, The University of Western Australia, 6907, Nedlands, Western Australia, Australia aut Anatomy and Embryology Springer-Verlag 193/2(1996-02-01), 169-173 0340-2061 193:2<169 1996 193 429 https://doi.org/10.1007/BF00214707 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00214707 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tennant Marc The Dental School, The University of Western Australia, 6907, Nedlands, Western Australia, Australia aut NATIONALLICENCE 700 1- McGeachie John Department of Anatomy and Human Biology, The University of Western Australia, 6907, Nedlands, Western Australia, Australia aut NATIONALLICENCE 773 0- Anatomy and Embryology Springer-Verlag 193/2(1996-02-01), 169-173 0340-2061 193:2<169 1996 193 429 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer