caa a22 4500 477095720 CHVBK 20180405111527.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/BF00196315 doi (NATIONALLICENCE)springer-10.1007/BF00196315 Development of nerve fibres in the temporomandibular joint of the human fetus [Elektronische Daten] [G. Ramieri, G. Bonardi, V. Morani, G. Preti, G. Panzica, F. Del Tetto, R. Arisio] The development of nerve fibres in the temporomandibular joint (TMJ) in relation to the development of bone, muscle and fibre components was investigated in human fetuses ranging from 9 weeks of gestation to birth. Immunohistochemistry for the glia-associated protein S-100 and for the neuro-specific marker protein gene product 9.5 (PGP 9.5) were used; specimens were compared to specimens of adult TMJ capsule and disc. At 9-10 weeks, a small number of neural elements are already present in the connective tissue around the joint and in the mesenchyme between the two articular blastemas from which the disc will differentiate. By 19 weeks many nerve fibres are clearly visible. Immunohistochemical results suggest diffuse disc innervation extending along the entire disc but not in the thin central area. More complex structures, i.e. encapsulated corpuscles, were also seen. The fetal disc appears highly innervated compared to adult tissue; already at this developmental stage morphology and distribution of nerves and corpuscles in the joint capsule are comparable to those in the adult joint. It may be concluded that the innervation of the TMJ is detectable from the end of the second month and that it develops fully between the third and the fifth month of gestation. Nerve endings in the disc are most numerous at 20 weeks, after which a progressive reduction, possibly secondary to the growth of articular tissues, is observed throughout the last trimester of fetal life and into adult life. The innervation of the lateral pterygoid muscle, on the contrary, is much less than that seen in adult muscles, even at full-term. Springer-Verlag, 1996 Embryology nationallicence Temporomandibular joint nationallicence PGP 9.5 nationallicence Innervation nationallicence Human nationallicence Ramieri G. Dipartimento di Fisiopatologia Clinica, Sezione di Chirurgia Maxillo-facciale, Università di Torino, Corso A.M. Dogliotti 14, 1-10126, Torino, Italy aut Bonardi G. Department of Prosthetic Dentistry, University of Turin, Italy aut Morani V. Department of Prosthetic Dentistry, University of Turin, Italy aut Preti G. Department of Prosthetic Dentistry, University of Turin, Italy aut Panzica G. Department of Anatomy and Physiology, University of Turin, Italy aut Del Tetto F. Department of Obstetrics and Gynecology, Mauriziano Hospital, Turin, Italy aut Arisio R. Department of Pathology, Sant' Anna Hospital, Turin, Italy aut Anatomy and Embryology Springer-Verlag 194/1(1996-07-01), 57-64 0340-2061 194:1<57 1996 194 429 https://doi.org/10.1007/BF00196315 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00196315 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ramieri G. Dipartimento di Fisiopatologia Clinica, Sezione di Chirurgia Maxillo-facciale, Università di Torino, Corso A.M. Dogliotti 14, 1-10126, Torino, Italy aut NATIONALLICENCE 700 1- Bonardi G. Department of Prosthetic Dentistry, University of Turin, Italy aut NATIONALLICENCE 700 1- Morani V. Department of Prosthetic Dentistry, University of Turin, Italy aut NATIONALLICENCE 700 1- Preti G. Department of Prosthetic Dentistry, University of Turin, Italy aut NATIONALLICENCE 700 1- Panzica G. Department of Anatomy and Physiology, University of Turin, Italy aut NATIONALLICENCE 700 1- Del Tetto F. Department of Obstetrics and Gynecology, Mauriziano Hospital, Turin, Italy aut NATIONALLICENCE 700 1- Arisio R. Department of Pathology, Sant' Anna Hospital, Turin, Italy aut NATIONALLICENCE 773 0- Anatomy and Embryology Springer-Verlag 194/1(1996-07-01), 57-64 0340-2061 194:1<57 1996 194 429 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer