caa a22 4500 477095828 CHVBK 20180405111527.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF00187472 doi (NATIONALLICENCE)springer-10.1007/BF00187472 Ontogeny of vasoactive intestinal peptide gene expression in rat brain [Elektronische Daten] [M. Graber, J. Burgunder] Vasoactive intestinal peptide (VIP) expression was studied during rat brain development using in situ hybridization histochemistry with a 48mer, S35-ATP-labeled probe. First expression of VIP was found in the lateral thalamus at E17, in a region later recognized as the reticular nucleus. At E19, VIP mRNA was also found in the hypothalamus, especially the suprachiasmatic nucleus. The only other prenatal localizations were the cortex and the brainstem. VIP expression continously matured during the first three postnatal weeks, and adultlike patterns were found at P22, when cerebral cortex, ventrolateral and reticular thalamic nuclei, suprachiasmatic nucleus were the regions with most prominent VIP expression. These results demonstrate the relatively late appearance of VIP gene expression in the rat forebrain as compared with peptides like SRIF and CCK, suggesting it does not have a major role in early brain maturation. Springer-Verlag, 1996 Neuropeptides nationallicence Hybridization histochemistry nationallicence Chemical anatomy nationallicence Ontogeny nationallicence Rat nationallicence Brain nationallicence Graber M. Neuromorphologisches Labor, Neurologische Klinik und Poliklinik der Universität, Inselspital, University of Berne, CH-3010, Berne, Switzerland aut Burgunder J. Neuromorphologisches Labor, Neurologische Klinik und Poliklinik der Universität, Inselspital, University of Berne, CH-3010, Berne, Switzerland aut Anatomy and Embryology Springer-Verlag 194/6(1996-12-01), 595-605 0340-2061 194:6<595 1996 194 429 https://doi.org/10.1007/BF00187472 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00187472 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Graber M. Neuromorphologisches Labor, Neurologische Klinik und Poliklinik der Universität, Inselspital, University of Berne, CH-3010, Berne, Switzerland aut NATIONALLICENCE 700 1- Burgunder J. Neuromorphologisches Labor, Neurologische Klinik und Poliklinik der Universität, Inselspital, University of Berne, CH-3010, Berne, Switzerland aut NATIONALLICENCE 773 0- Anatomy and Embryology Springer-Verlag 194/6(1996-12-01), 595-605 0340-2061 194:6<595 1996 194 429 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 266012612 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer