caa a22 4500 477095909 CHVBK 20180405111527.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF00187473 doi (NATIONALLICENCE)springer-10.1007/BF00187473 Development and ageing of the articular cartilage of the rabbit knee joint: distribution of the fibrillar collagens [Elektronische Daten] [Yvette Bland, Doreen Ashhurst] The development of the articular cartilage of the rabbit knee joint from the 17-day fetus to the 2-year adult rabbit has been examined. At 17 days, the developing femur and tibia are separated by the interzone. Cavitation occurs around 25 days; the cells of the intermediate layer flatten and move onto those of the chondogenous layers to create the articular surfaces. After birth, growth of the cartilage is mainly the result of matrix production. Ossification of the epiphyses is complete by 6 weeks postpartum. Horizontal zones can be distinguished in the articular cartilage; the superficial cells are aligned parallel to the surface, but in the deep layers the cells are in columns. The tidemark is first seen at 12-14 weeks. The matrix of the interzone in the 17-day fetus contains types I, III and V collagens, but no type II. After cavitation at 25 days, the surface layer of the articular cartilage still contains type I, but no type II collagen. From 6 weeks postnatal onwards, type II collagen is present throughout the cartilage and type I disappears. Type III collagen is initially in the interterritorial matrix, but later it is mainly pericellular. Type V collagen is pericellular both in the chondrogenous layers and later in the articular cartilage, but is not present in the epiphyseal cartilage below. From 6 weeks onwards, types III and V collagens create a capsule around all the chondrocytes above the tidemark. The relationship of types V and XI collagens is discussed. It is concluded that the articular chondrocytes form a unique subset of cells from the earliest stages of joint formation in the fetal rabbit. Springer-Verlag, 1996 Cavitation nationallicence Bone nationallicence Immunohistochemistry nationallicence In situ hybridization nationallicence Bland Yvette Department of Anatomy, St. George's Hospital Medical School, Tooting, SW17 ORE, London, UK aut Ashhurst Doreen Department of Anatomy, St. George's Hospital Medical School, Tooting, SW17 ORE, London, UK aut Anatomy and Embryology Springer-Verlag 194/6(1996-12-01), 607-619 0340-2061 194:6<607 1996 194 429 https://doi.org/10.1007/BF00187473 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00187473 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bland Yvette Department of Anatomy, St. George's Hospital Medical School, Tooting, SW17 ORE, London, UK aut NATIONALLICENCE 700 1- Ashhurst Doreen Department of Anatomy, St. George's Hospital Medical School, Tooting, SW17 ORE, London, UK aut NATIONALLICENCE 773 0- Anatomy and Embryology Springer-Verlag 194/6(1996-12-01), 607-619 0340-2061 194:6<607 1996 194 429 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer