caa a22 4500 477095992 CHVBK 20180405111527.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF00187132 doi (NATIONALLICENCE)springer-10.1007/BF00187132 Ontogeny of GABA-immunoreactive cells in the primate cerebellar cortex: comparison with somatostatin-immunoreactivity [Elektronische Daten] [Akiko Yamashita, Motoharu Hayashi] The distribution and ontogeny of GABA-immunoreactive cells were studied and compared with that of somatostatin-immunoreactivity in the primate cerebellar cortex. At embryonic day 80, we observed neither GABA-nor somatostatin-immunoreactive cells in the cerebellum. At embryonic day 110, a small number of GABA-immunoreactive cells was detectable in the granular layer only, and these cells seemed to be Golgi cells. At embryonic day 140, although almost all Purkinje cells were somatostatin-immunoreactive, a proportion of these cells was GABA-immunoreactive. At the newborn stage, most of the Purkinje cells were GABA-immunoreactive and almost all of them were also somatostatin-immunoreactive. During the postnatal stages, the number of somatostatin-immunoreactive cells decreased until postnatal day 60. At the adult stage, a large number of Purkinje cell bodies was faintly GABA-immunoreactive and a proportion of Purkinje cell dendrites was GABA-immunoreactive. In the aged animals (28 and 31 years old), a small number of Purkinje cell dendrites was GABA-immunoreactive. These findings suggest that a transition of phenotype from somatostatin to GABA occurred in Purkinje cells during development. Springer-Verlag, 1996 γ-aminobutyric acid nationallicence Cerebellum nationallicence Development nationallicence Macaque monkey nationallicence Phenotype change nationallicence Ad : Adult nationallicence EX : embryonic day X nationallicence GABA : γ-aminobutyric acid nationallicence GAD : glutamic acid decarboxylase nationallicence ir : immunoreactive nationallicence Nb : newborn (postnatal day 1-3) nationallicence NGF : nerve growth factor nationallicence PX : postnatal day X nationallicence PXy : X years old nationallicence P8y : < more than 8 years old nationallicence PBS : phosphate-buffered saline nationallicence PL : Purkinje cell layer nationallicence SOM : somatostatin nationallicence WM : white matter nationallicence Yamashita Akiko Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University, Inuyama, Aichi, Japan aut Hayashi Motoharu Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University, Inuyama, Aichi, Japan aut Anatomy and Embryology Springer-Verlag 194/3(1996-09-01), 215-222 0340-2061 194:3<215 1996 194 429 https://doi.org/10.1007/BF00187132 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00187132 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yamashita Akiko Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University, Inuyama, Aichi, Japan aut NATIONALLICENCE 700 1- Hayashi Motoharu Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University, Inuyama, Aichi, Japan aut NATIONALLICENCE 773 0- Anatomy and Embryology Springer-Verlag 194/3(1996-09-01), 215-222 0340-2061 194:3<215 1996 194 429 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer