caa a22 4500 477096050 CHVBK 20180405111527.0 cr unu---uuuuu 170330e19961001xx s 000 0 eng 10.1007/BF00198544 doi (NATIONALLICENCE)springer-10.1007/BF00198544 Developmental change in expression of highly polysialylated neural cell adhesion molecule in C-cells in rat thyroid gland [Elektronische Daten] [Ichiro Nishiyama, Manabu Ogiso, Tadachika Oota, Takako Kimura, Tatsunori Seki] The expression of the neural cell adhesion molecule (NCAM), highly polysialylated NCAM, and Ecadherin was immunohistochemically studied in the calcitonin-producing cells (C-cells) of developing and adult rat thyroid glands of varying ages. In fetal and neonatal rat thyroids, almost all the C-cells displayed immunoreactivity for highly polysialylated NCAM, whereas most of the follicular cells were negative. The highly polysialylated NCAM-positive C-cells markedly decreased in number between 5 and 14 days after birth. From day 14 onward, immunoreactivity for highly polysialylated NCAM was almost negative in thyroid glands. On the other hand, the expression of immunoreactivity for NCAM peptide persisted in thyroidal C-cells throughout the life span. These results suggest that conversion of the highly polysialylated NCAM into a less sialylated form occurs in the thyroid C-cells between postnatal days 5 and 14. Intense immunoreactivity for E-cadherin was observed in the entire cell surfaces of all the C-cells and follicular cells in the rats of all ages tested. In the course of thyroid organogenesis, C-cells transiently form a cell mass, an ultimobranchial body, which is fated to disappear as the C-cells migrate diffusely into the thyroid. The duration of the polysialic acid expression in the C-cell surfaces appears to coincide with the period of C-cell migration. It is possible that the expression of highly polysialylated NCAM allows the C-cells to migrate into the thyroid by reducing the cell-to-cell adhesion of C-cells with adjacent C-cells and/or with the surrounding follicular cells. Springer-Verlag, 1996 Calcitonin nationallicence Ultimobranchial body nationallicence Cell adhesion nationallicence Polysialic acid nationallicence E-Cadherin nationallicence Nishiyama Ichiro Biological Laboratory, Komazawa Women's University, 238 Sakahama, Inagi, 206, Tokyo, Japan aut Ogiso Manabu Cell and Information, PRESTO, Research Development Corporation of Japan (JRDC), Japan aut Oota Tadachika Isotope Center, Tokyo University of Agriculture, 156, Tokyo, Japan aut Kimura Takako Department of Domestic Science, Komazawa Women's Junior College, 206, Tokyo, Japan aut Seki Tatsunori Department of Anatomy, Juntendo University School of Medicine, 113, Tokyo, Japan aut Anatomy and Embryology Springer-Verlag 194/4(1996-10-01), 419-426 0340-2061 194:4<419 1996 194 429 https://doi.org/10.1007/BF00198544 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00198544 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nishiyama Ichiro Biological Laboratory, Komazawa Women's University, 238 Sakahama, Inagi, 206, Tokyo, Japan aut NATIONALLICENCE 700 1- Ogiso Manabu Cell and Information, PRESTO, Research Development Corporation of Japan (JRDC), Japan aut NATIONALLICENCE 700 1- Oota Tadachika Isotope Center, Tokyo University of Agriculture, 156, Tokyo, Japan aut NATIONALLICENCE 700 1- Kimura Takako Department of Domestic Science, Komazawa Women's Junior College, 206, Tokyo, Japan aut NATIONALLICENCE 700 1- Seki Tatsunori Department of Anatomy, Juntendo University School of Medicine, 113, Tokyo, Japan aut NATIONALLICENCE 773 0- Anatomy and Embryology Springer-Verlag 194/4(1996-10-01), 419-426 0340-2061 194:4<419 1996 194 429 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer