caa a22 4500 477096174 CHVBK 20180405111528.0 cr unu---uuuuu 170330e19961101xx s 000 0 eng 10.1007/BF00185995 doi (NATIONALLICENCE)springer-10.1007/BF00185995 Age-related changes in the localization of glycosaminoglycans in condylar cartilage of the mandible in rats [Elektronische Daten] [I. Takahashi, I. Mizoguchi, Y. Sasano, S. Saitoh, M. Ishida, M. Kagayama, H. Mitani] There is little information available regarding the morphological and biomolecular characteristics of mandibular condylar cartilage. The purpose of this study was to determine the age-related changes in the morphology and immunolocalization of glycosaminoglycans (GAGs) in mandibular condyles. The mandibular condylar cartilages from 4-, 8-, 16-, 32-, and 64-week-old Wistar male rats were examined to verify the localization of chondroitin-4-sulfate (Ch-4S), chondroitin-6-sulfate (Ch-6S) and keratan sulfate (KS) using an indirect immunofluorescent technique with three monoclonal antibodies for glycosaminoglycans, 2-B-6, 3-B-3 and 5-D-4, respectively. Morphologically, the condylar cartilage was a growth cartilage during growing periods, began to differentiate into articular cartilage from the central area of 16-week-old condyles, and became mature articular cartilage at 32 weeks of age. A regional difference was found in the morphological features and distribution of GAGs between the anterior, central, postero-superior and posterior areas of the condyles at each age. The immunohistochemical localizations of these three glycosaminoglycans showed age-related, morphology-dependent changes, from growth cartilage to articular cartilage-like cartilage. Immunoreactions for all of the antibodies decreased progressively with age in the interterritorial matrix, while the pericellular and territorial matrix in the condylar cartilage of the mandible maintained relatively higher immunoreactivity. In conclusion, age-related and regional differences in the localization of glycosaminoglycans Ch-4S, Ch-6S, and KS were found in the mandibular condyles in rats, and these changes are believed to be related to functional and developmental requirements. Springer-Verlag, 1996 Temporomandibular joint nationallicence Immunohistochemistry nationallicence Proteoglycan nationallicence Aging nationallicence Development nationallicence Takahashi I. Department of Orthodontics, School of Dentistry, Tohoku University, 4-1, Seiryomachi, Aoba-ku, 980-77, Sendai, Japan aut Mizoguchi I. Department of Orthodontics, School of Dentistry, Tohoku University, 4-1, Seiryomachi, Aoba-ku, 980-77, Sendai, Japan aut Sasano Y. 2nd Department of Oral Anatomy, School of Dentistry, Tohoku University, 4-1, Seiryo-machi, Aoba-ku, 980-77, Sendai, Japan aut Saitoh S. Department of Orthodontics, School of Dentistry, Tohoku University, 4-1, Seiryomachi, Aoba-ku, 980-77, Sendai, Japan aut Ishida M. Department of Orthodontics, School of Dentistry, Tohoku University, 4-1, Seiryomachi, Aoba-ku, 980-77, Sendai, Japan aut Kagayama M. 2nd Department of Oral Anatomy, School of Dentistry, Tohoku University, 4-1, Seiryo-machi, Aoba-ku, 980-77, Sendai, Japan aut Mitani H. Department of Orthodontics, School of Dentistry, Tohoku University, 4-1, Seiryomachi, Aoba-ku, 980-77, Sendai, Japan aut Anatomy and Embryology Springer-Verlag 194/5(1996-11-01), 489-500 0340-2061 194:5<489 1996 194 429 https://doi.org/10.1007/BF00185995 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00185995 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takahashi I. Department of Orthodontics, School of Dentistry, Tohoku University, 4-1, Seiryomachi, Aoba-ku, 980-77, Sendai, Japan aut NATIONALLICENCE 700 1- Mizoguchi I. Department of Orthodontics, School of Dentistry, Tohoku University, 4-1, Seiryomachi, Aoba-ku, 980-77, Sendai, Japan aut NATIONALLICENCE 700 1- Sasano Y. 2nd Department of Oral Anatomy, School of Dentistry, Tohoku University, 4-1, Seiryo-machi, Aoba-ku, 980-77, Sendai, Japan aut NATIONALLICENCE 700 1- Saitoh S. Department of Orthodontics, School of Dentistry, Tohoku University, 4-1, Seiryomachi, Aoba-ku, 980-77, Sendai, Japan aut NATIONALLICENCE 700 1- Ishida M. Department of Orthodontics, School of Dentistry, Tohoku University, 4-1, Seiryomachi, Aoba-ku, 980-77, Sendai, Japan aut NATIONALLICENCE 700 1- Kagayama M. 2nd Department of Oral Anatomy, School of Dentistry, Tohoku University, 4-1, Seiryo-machi, Aoba-ku, 980-77, Sendai, Japan aut NATIONALLICENCE 700 1- Mitani H. Department of Orthodontics, School of Dentistry, Tohoku University, 4-1, Seiryomachi, Aoba-ku, 980-77, Sendai, Japan aut NATIONALLICENCE 773 0- Anatomy and Embryology Springer-Verlag 194/5(1996-11-01), 489-500 0340-2061 194:5<489 1996 194 429 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer