caa a22 4500 477096190 CHVBK 20180405111528.0 cr unu---uuuuu 170330e19961101xx s 000 0 eng 10.1007/BF00185997 doi (NATIONALLICENCE)springer-10.1007/BF00185997 Spatial and temporal pattern of smooth muscle cell differentiation during development of the vascular system in the mouse embryo [Elektronische Daten] [Yu Takahashi, Tsuneo Imanaka, Tatsuya Takano] The initial phase of smooth muscle differentiation in the vascular system of the mouse embryo was observed immunohistochemically with monoclonal antibody against α-smooth muscle actin. Few smooth muscle cells were detected in the vascular system of the 9.5-day embryo, where only the dorsal aorta and umbilical artery showed signs of smooth muscle differentiation. In the 10.5-day embryo, smooth muscle cells were observed in the dorsal aorta, ventral aorta, omphalomesenteric artery and vein, umbilical artery and vein, internal carotid artery, aortic arches III and IV, and subclavian artery. The extent of smooth muscle differentiation varied among these vessels and among regions of a vessel. At 11.5 days of gestation, smooth muscle cells appeared in the basilar artery, vertebral artery, aortic arches VI, intersomitic artery, ductus venosus, and caudal artery. Smooth muscle cells were absent from the venous system characteristic of the embryo at the stages examined. Alpha-smooth muscle actin-positive cells were also observed in allantoic mesoderm in the placenta at 9.5 days, when the umbilical vessels were not surrounded by smooth muscle cells. Vascular smooth muscle cells appear to arise independently from mesenchyme at multiple sites in the vascular system. Springer-Verlag, 1996 Vascular system nationallicence Smooth muscle cell nationallicence Immunohistochemistry nationallicence α-smooth muscle actin nationallicence Mouse embryo nationallicence Takahashi Yu Department of Microbiology and Molecular Pathology, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, 199-01, Kanagawa, Japan aut Imanaka Tsuneo Department of Microbiology and Molecular Pathology, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, 199-01, Kanagawa, Japan aut Takano Tatsuya Department of Microbiology and Molecular Pathology, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, 199-01, Kanagawa, Japan aut Anatomy and Embryology Springer-Verlag 194/5(1996-11-01), 515-526 0340-2061 194:5<515 1996 194 429 https://doi.org/10.1007/BF00185997 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00185997 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takahashi Yu Department of Microbiology and Molecular Pathology, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, 199-01, Kanagawa, Japan aut NATIONALLICENCE 700 1- Imanaka Tsuneo Department of Microbiology and Molecular Pathology, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, 199-01, Kanagawa, Japan aut NATIONALLICENCE 700 1- Takano Tatsuya Department of Microbiology and Molecular Pathology, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, 199-01, Kanagawa, Japan aut NATIONALLICENCE 773 0- Anatomy and Embryology Springer-Verlag 194/5(1996-11-01), 515-526 0340-2061 194:5<515 1996 194 429 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer