caa a22 4500 477098630 CHVBK 20180405111534.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF02616288 doi (NATIONALLICENCE)springer-10.1007/BF02616288 Gene therapy in surgery [Elektronische Daten] Part I: Methods for Gene Transfer—Application to Cancer [M. Rogy, Julie Baumhofer, Britta Beinhauer, H. Brandmeier, P. Eisenburger, U. Losert, Ramila Philip] Gentherapeutische Strategien in der Chirurgie Teil I: Methodik des Gentransfers—Anwendung bei Krebserkrankungen Summary: Background: With the increasing body of knowledge in molecular biology, gene transfer respectively gene therapy becomes more and more a valid therapeutic option. Methods: This is a critical review of gene therapy protocols for treatment of different types of cancer. Furthermore, the pathophysiological mechanism, therapeutically strategies as well as experimental approaches toward gene transfer in septic shock and organ transplantation are critically elucidated. Results: Gene transfer as a therapeutic option was first successfully applied in children with severe combined immunodeficiency (SCID) in 1990. The majority of gene marking or gene therapy protocols approved for human clinical trials to date are related to the treatment of cancer. Besides viral vectors for brain tumors, non-viral vectors, liposomes particularly, with almost no side effects are increasingly used. Conclusions: Different approaches of gene transfer in cancer patients are under investigation. Experimental data of septic shock treatment and rejection therapy of the allograft in organ recipients with gene transfer are encouraging for future applications in clinical trials. Blackwell Science Ltd, 1996 Gene therapy nationallicence cancer nationallicence septic shock nationallicence organ transplantation nationallicence Gentherapie nationallicence Karzinome nationallicence septischer Schock nationallicence Organtransplantation nationallicence Rogy M. Department of Surgery, Division of General Surgery and, University of Vienna, Währinger Gürtel 18-20, A-1090, Austria aut Baumhofer Julie Department of Surgery, Division of General Surgery and, University of Vienna, Währinger Gürtel 18-20, A-1090, Austria aut Beinhauer Britta Department of Surgery, Division of General Surgery and, University of Vienna, Währinger Gürtel 18-20, A-1090, Austria aut Brandmeier H. Department of Surgery, Division of General Surgery and, University of Vienna, Währinger Gürtel 18-20, A-1090, Austria aut Eisenburger P. Department of Surgery, Division of General Surgery and, University of Vienna, Währinger Gürtel 18-20, A-1090, Austria aut Losert U. Center of Biomedical Research, University of Vienna, A-1090, Austria aut Philip Ramila Applied Immune Science, Santa Clara, Clifornia, USA aut Acta Chirurgica Austriaca Springer-Verlag 28/6(1996-12-01), 358-361 0001-544X 28:6<358 1996 28 10353 https://doi.org/10.1007/BF02616288 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02616288 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rogy M. Department of Surgery, Division of General Surgery and, University of Vienna, Währinger Gürtel 18-20, A-1090, Austria aut NATIONALLICENCE 700 1- Baumhofer Julie Department of Surgery, Division of General Surgery and, University of Vienna, Währinger Gürtel 18-20, A-1090, Austria aut NATIONALLICENCE 700 1- Beinhauer Britta Department of Surgery, Division of General Surgery and, University of Vienna, Währinger Gürtel 18-20, A-1090, Austria aut NATIONALLICENCE 700 1- Brandmeier H. Department of Surgery, Division of General Surgery and, University of Vienna, Währinger Gürtel 18-20, A-1090, Austria aut NATIONALLICENCE 700 1- Eisenburger P. Department of Surgery, Division of General Surgery and, University of Vienna, Währinger Gürtel 18-20, A-1090, Austria aut NATIONALLICENCE 700 1- Losert U. Center of Biomedical Research, University of Vienna, A-1090, Austria aut NATIONALLICENCE 700 1- Philip Ramila Applied Immune Science, Santa Clara, Clifornia, USA aut NATIONALLICENCE 773 0- Acta Chirurgica Austriaca Springer-Verlag 28/6(1996-12-01), 358-361 0001-544X 28:6<358 1996 28 10353 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer