caa a22 4500 477099386 CHVBK 20180405111536.0 cr unu---uuuuu 170330e19961001xx s 000 0 eng 10.1007/BF02629281 doi (NATIONALLICENCE)springer-10.1007/BF02629281 Surgery for pheochromocytoma in MEN II patients— a radical versus a limited approach [Elektronische Daten] [P. Goretzki, D. Simon, Cornelia Dotzenrath, H. Röher] Chirurgie des Phäochromozytoms bei MEN-II-Patienten— Radikale versus limitierte Chirurgie Summary: Background: Bilateral versus unilateral or subtotal adrenalectomy in MEN II patients with associated pheochromocytoma is subject to controversial discussion. The aim of this study was to compare the two procedures with regard to surgical approach and postoperative recurrence rate. Methods: Between 1986 and 1995, 14 of 52 patients with MEN II syndrome were operated on for pheochromocytoma. The pheochromocytoma was the first manifestation of the syndrome in 4 of the patients, and in another 4 patients pheochromocytoma was simultaneously present with medullary thyroid cancer (MTC). Preoperative imaging correctly localized the tumor in all patients (CT 12/13 [92%]; MIBG 6/6 [100%]). Operative procedures included unilateral adrenalectomy in 7 patients, subtotal resection in 3, and bilateral total adrenalectomy in 4 patients. Transabdominal incision was performed on 11 patients, and a lateral, extraperitoneal approach was done in 3 patients. 2 patients had malignant pheochromocytomas. Results: During a mean follow-up period of 4.9 years (range 0.5 to 14 years), 3 patients developed recurrent disease after unilateral adrenalectomy. 1 patient died of malignant pheochromocytoma, and 1 from metastatic MTC. The remaining 9 patients presently are clinically and biochemically free of disease. In the 3 patients with subtotal adrenalectomy, the adrenal remmants are clinically intact and functioning without any need for cortisol substitution. Conclusions: Exact preoperative localization does on principle not require bilateral exploration and allows a unilateral extraperitoneal approach with long, disease-free intervals. Whether subtotal adrenal resection is a further alternative to unilateral adrenalectomy with identical and functionally good results, as well as lower recurrence rates will have to be investigated in future studies. Blackwell Science Ltd, 1996 Phäochromozytom bei MEN II nationallicence chirurgische Therapie nationallicence Pheochromocytoma in MEN II nationallicence surgical therapy nationallicence Goretzki P. Department of Visceral and Trauma Surgery, Heinrich Heine University, Moorenstraße 5, D-40225, Düsseldorf, Germany aut Simon D. Department of Visceral and Trauma Surgery, Heinrich Heine University, Moorenstraße 5, D-40225, Düsseldorf, Germany aut Dotzenrath Cornelia Department of Visceral and Trauma Surgery, Heinrich Heine University, Moorenstraße 5, D-40225, Düsseldorf, Germany aut Röher H. Department of Visceral and Trauma Surgery, Heinrich Heine University, Moorenstraße 5, D-40225, Düsseldorf, Germany aut Acta Chirurgica Austriaca Springer-Verlag 28/5(1996-10-01), 296-299 0001-544X 28:5<296 1996 28 10353 https://doi.org/10.1007/BF02629281 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02629281 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Goretzki P. Department of Visceral and Trauma Surgery, Heinrich Heine University, Moorenstraße 5, D-40225, Düsseldorf, Germany aut NATIONALLICENCE 700 1- Simon D. Department of Visceral and Trauma Surgery, Heinrich Heine University, Moorenstraße 5, D-40225, Düsseldorf, Germany aut NATIONALLICENCE 700 1- Dotzenrath Cornelia Department of Visceral and Trauma Surgery, Heinrich Heine University, Moorenstraße 5, D-40225, Düsseldorf, Germany aut NATIONALLICENCE 700 1- Röher H. Department of Visceral and Trauma Surgery, Heinrich Heine University, Moorenstraße 5, D-40225, Düsseldorf, Germany aut NATIONALLICENCE 773 0- Acta Chirurgica Austriaca Springer-Verlag 28/5(1996-10-01), 296-299 0001-544X 28:5<296 1996 28 10353 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer