caa a22 4500 477103405 CHVBK 20180405111547.0 cr unu---uuuuu 170330e19961001xx s 000 0 eng 10.1007/BF03048673 doi (NATIONALLICENCE)springer-10.1007/BF03048673 Multimodal strategy in locally advanced inoperable head and neck cancer [Elektronische Daten] A pilot study [Narendra Deo, M. Gupta, B. Shrivastava, K. Agrawal] Squamous cell carcinoma of the Head and Neck is the commonest cancer at our centre and the majority were in locally advanced inoperable stage (stage III and IV) where surgery and/or radiotherapy were able to cure less than 10% of the patients. This study was conducted to determine the role of neo-adjuvant chemotherapy in these cases and to bring locally advanced inoperable disease within perview of surgery and/ or curative radiotherapy. A total of 32 patients found inoperable or unsuitable for curative radiotherapy were treated with neoadjuvant chemotherapy (Cisplatinum, 5FU, Bleomycin and Hydroxyurea × 3 cycles) followed by surgery and or radiotherapy. All the patients were evaluable for response. An objective response rate following neoadjuvant chemotherapy was 81% (28% CR, 53% PR). Subsequent surgery or radiotherapy were able to have 56.25% (18/32) of patients disease free at 4 years with overall survival 46.8% at 4 years. Neoadjuvant chemotherapy along with radiotherapy and/or surgery might be an effective protocol in controlling advanced inoperable head and neck squamous cell carcinoma. Association of Otolaryngologists of India, 1996 Deo Narendra Surgical Oncology, Cancer Hospital & Research Institute, Gwalior (M.P.), India aut Gupta M. Cancer Hospital & Research Institute, Gwalior (M.P.), India aut Shrivastava B. Cancer Hospital & Research Institute, Gwalior (M.P.), India aut Agrawal K. Cancer Hospital & Research Institute, Gwalior (M.P.), India aut Indian Journal of Otolaryngology and Head and Neck Surgery Springer India 48/4(1996-10-01), 327-330 0019-5421 48:4<327 1996 48 12070 https://doi.org/10.1007/BF03048673 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03048673 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Deo Narendra Surgical Oncology, Cancer Hospital & Research Institute, Gwalior (M.P.), India aut NATIONALLICENCE 700 1- Gupta M. Cancer Hospital & Research Institute, Gwalior (M.P.), India aut NATIONALLICENCE 700 1- Shrivastava B. Cancer Hospital & Research Institute, Gwalior (M.P.), India aut NATIONALLICENCE 700 1- Agrawal K. Cancer Hospital & Research Institute, Gwalior (M.P.), India aut NATIONALLICENCE 773 0- Indian Journal of Otolaryngology and Head and Neck Surgery Springer India 48/4(1996-10-01), 327-330 0019-5421 48:4<327 1996 48 12070 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer