caa a22 4500 477105475 CHVBK 20180405111552.0 cr unu---uuuuu 170330e19961101xx s 000 0 eng 10.1007/BF01574770 doi (NATIONALLICENCE)springer-10.1007/BF01574770 Occurrence of cyclosporins and cyclosporin-like peptolides in fungi [Elektronische Daten] [R Traber, M Dreyfuss] Apart from 17 previously listed fungal taxa producing cyclosporin A and its natural congeners B to Z, several additional and taxonomically diverse strains producing the single novel component [Thr2, Leu5, Leu10]cyclosporin or cyclosporin-like peptolides (eg SDZ 214-103=[Thr2, Leu5, D-Hiv8, Leu10]cyclosporin) have recently been described. We report here the isolation of two further and novel cyclosporins, [Thr2, Leu5, Ala10]cyclosporin (2) and [Thr2, Ile5] cyclosporin (3), from strains classified asAcremonium luzulae (Fuckel) W Gams andLeptostroma anamorph ofHypoderma eucalyptii Cooke & Harkn, respectively. In both new strains the usual pattern of cyclosporins A to Z is not found. The structure elucidations of2 and3 are based on NMR spectroscopy, and biological data (immunosuppressive activity, cyclophilin-binding affinity and antifungal effects) are presented. Society for Industrial Microbiology, 1996 cyclosporins nationallicence cyclosporin-like peptolides nationallicence fungal taxa nationallicence Acremonium luzulae nationallicence Leptostroma anamorph of Hypoderma eucalyptii nationallicence Traber R. Preclinical Research, Sandoz Pharma Ltd, CH-4002, Basel, Switzerland aut Dreyfuss M. Preclinical Research, Sandoz Pharma Ltd, CH-4002, Basel, Switzerland aut Journal of Industrial Microbiology Springer-Verlag 17/5-6(1996-11-01), 397-401 0169-4146 17:5-6<397 1996 17 10295 https://doi.org/10.1007/BF01574770 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01574770 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Traber R. Preclinical Research, Sandoz Pharma Ltd, CH-4002, Basel, Switzerland aut NATIONALLICENCE 700 1- Dreyfuss M. Preclinical Research, Sandoz Pharma Ltd, CH-4002, Basel, Switzerland aut NATIONALLICENCE 773 0- Journal of Industrial Microbiology Springer-Verlag 17/5-6(1996-11-01), 397-401 0169-4146 17:5-6<397 1996 17 10295 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer