caa a22 4500 477105548 CHVBK 20180405111552.0 cr unu---uuuuu 170330e19961101xx s 000 0 eng 10.1007/BF01574773 doi (NATIONALLICENCE)springer-10.1007/BF01574773 Autocides and a paracide, antibiotic TA, produced by Myxococcus xanthus [Elektronische Daten] [E Rosenberg, M Dworkin] Myxococcus xanthus produces two categories of low molecular weight antibacterial materials, autocides and paracides, that have diametrically opposite host ranges. Low concentrations of autocides lyseM. xanthus, the producing organism, whereas paracides exert their effects on other bacteria. Antibiotic TA (a paracide) kills all growing bacteria tested that have a peptidoglycan cell wall exceptM. xanthus. It is a macrocyclic polyketide with a molecular weight of 623. The two major autocides produced byM. xanthus are phosphatidylethanolamine and a mixture of fatty acids. The modes of action, host ranges and biosynthesis of antibiotic TA and the autocides are presented, and then an attempt is made to explain their role in the complex life cycle ofM. xanthus. In addition, the remarkable adhesion properties of antibiotic TA and a new semisynthetic derivative of it, focusin, are presented. Society for Industrial Microbiology, 1996 M. xanthus nationallicence antibiotic TA nationallicence autocide nationallicence paracide nationallicence autolysis nationallicence development nationallicence focusin nationallicence Rosenberg E. Department of Molecular Microbiology and Biotechnology, George S Wise Faculty of Wife Sciences, Tel Aviv University, 69978, Ramat Aviv, Israel aut Dworkin M. Department of Microbiology, University of Minnesota, UMHC Box 196, 55455-0312, Minneapolis, Minnesota, USA aut Journal of Industrial Microbiology Springer-Verlag 17/5-6(1996-11-01), 424-431 0169-4146 17:5-6<424 1996 17 10295 https://doi.org/10.1007/BF01574773 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01574773 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rosenberg E. Department of Molecular Microbiology and Biotechnology, George S Wise Faculty of Wife Sciences, Tel Aviv University, 69978, Ramat Aviv, Israel aut NATIONALLICENCE 700 1- Dworkin M. Department of Microbiology, University of Minnesota, UMHC Box 196, 55455-0312, Minneapolis, Minnesota, USA aut NATIONALLICENCE 773 0- Journal of Industrial Microbiology Springer-Verlag 17/5-6(1996-11-01), 424-431 0169-4146 17:5-6<424 1996 17 10295 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer