caa a22 4500 477106153 CHVBK 20180405111554.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/BF01570039 doi (NATIONALLICENCE)springer-10.1007/BF01570039 Improvement of the kirromycin fermentation by resin addition [Elektronische Daten] [L Gastaldo, F Marinelli, C Acquarella, E Restelli, C Quarta] The kirromycin yield ofActinoplanes sp A8924 was improved from 30-50 mg L−1 to 350 mg L−1 by mutant selection and medium optimization. The incorporation of polystyrenic resins into the fermentations promoted a further fourfold enhancement of kirromycin productivity to 1500 mg L−1. The positive effect of resin addition appears to be due to removal of kirromycin from the fermentation broth because kirromycin's minimal inhibitory concentration against the producing strain remained atca 350 mg L−1. Society for Industrial Microbiology, 1996 aurodox nationallicence kirromycin nationallicence antibiotic nationallicence production yield nationallicence resin nationallicence end-product toxicity nationallicence Gastaldo L. Lepetit Research Center, Via R Lepetit 34, 21040, Gerenzano (VA), Italy aut Marinelli F. Lepetit Research Center, Via R Lepetit 34, 21040, Gerenzano (VA), Italy aut Acquarella C. Lepetit Research Center, Via R Lepetit 34, 21040, Gerenzano (VA), Italy aut Restelli E. Lepetit Research Center, Via R Lepetit 34, 21040, Gerenzano (VA), Italy aut Quarta C. Lepetit Research Center, Via R Lepetit 34, 21040, Gerenzano (VA), Italy aut Journal of Industrial Microbiology Springer-Verlag 16/5(1996-05-01), 305-308 0169-4146 16:5<305 1996 16 10295 https://doi.org/10.1007/BF01570039 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01570039 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gastaldo L. Lepetit Research Center, Via R Lepetit 34, 21040, Gerenzano (VA), Italy aut NATIONALLICENCE 700 1- Marinelli F. Lepetit Research Center, Via R Lepetit 34, 21040, Gerenzano (VA), Italy aut NATIONALLICENCE 700 1- Acquarella C. Lepetit Research Center, Via R Lepetit 34, 21040, Gerenzano (VA), Italy aut NATIONALLICENCE 700 1- Restelli E. Lepetit Research Center, Via R Lepetit 34, 21040, Gerenzano (VA), Italy aut NATIONALLICENCE 700 1- Quarta C. Lepetit Research Center, Via R Lepetit 34, 21040, Gerenzano (VA), Italy aut NATIONALLICENCE 773 0- Journal of Industrial Microbiology Springer-Verlag 16/5(1996-05-01), 305-308 0169-4146 16:5<305 1996 16 10295 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer