caa a22 4500 477106501 CHVBK 20180405111555.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF01411727 doi (NATIONALLICENCE)springer-10.1007/BF01411727 Cerebral haemodynamic considerations in obstructive carotid artery disease [Elektronische Daten] [A. Sorteberg, W. Sorteberg, K. Lindegaard, H. Nornes] Summary: 46 subjects with obstructive carotid artery disease were investigated with transcranial Doppler ultrasonography. Their baseline blood velocities (V) in the middle, anterior and posterior cerebral artery (MCA, ACA and PCA) and in the extracranial internal carotid artery (ICA) were measured and the pulsatility index (PI) calculated for each vessel. Thereafter the vasomotor reserve in both MCAs was tested. Typical patterns of V, PI and vasomotor reactivity are presented. Arterial collaterals were recognized by their relatively increased velocities. We demonstrated a close association of the baseline variables V and PI and the total vasomotor reactivity (hypocapnic plus no, hypercapnic response) by calculating an index of Uhem related to the cerebrovascular tone. The Uhem index is expressed by: Uhem index = VMCA·PIMCA/VPCA·PIPCA The relationship between Uhem index and the total vasomotor reactivity seemed to correspond to a hyperbolic curve. The hyperbolic tangent of Uhem index and total vasomotor reactivity correlated highly significantly, r = 0.8203, p < 0.0001, n = 49, the best fit for the regression line was Y = −0.005+Uhem index 51.3. On the 99% significance level an Uhem index ⩾0.94 indicated normal total cerebral vasomotor reactivity in contrast to an impaired reactivity when ⩽0.81. Findings in 20 patients investigated post hoc supported the validity of our concept. Springer-Verlag, 1996 Transcranial Doppler sonography nationallicence vasomotor reserve nationallicence arterial collaterals nationallicence cerebrovascular impedance nationallicence Sorteberg A. Department of Neurosurgery, Rikshospitalet, The National Hospital, University of Oslo, Oslo, Norway aut Sorteberg W. Department of Neurosurgery, Rikshospitalet, The National Hospital, University of Oslo, Oslo, Norway aut Lindegaard K. Department of Neurosurgery, Rikshospitalet, The National Hospital, University of Oslo, Oslo, Norway aut Nornes H. Department of Neurosurgery, Rikshospitalet, The National Hospital, University of Oslo, Oslo, Norway aut Acta Neurochirurgica Springer-Verlag 138/1(1996-01-01), 68-76 0001-6268 138:1<68 1996 138 701 https://doi.org/10.1007/BF01411727 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01411727 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sorteberg A. Department of Neurosurgery, Rikshospitalet, The National Hospital, University of Oslo, Oslo, Norway aut NATIONALLICENCE 700 1- Sorteberg W. Department of Neurosurgery, Rikshospitalet, The National Hospital, University of Oslo, Oslo, Norway aut NATIONALLICENCE 700 1- Lindegaard K. Department of Neurosurgery, Rikshospitalet, The National Hospital, University of Oslo, Oslo, Norway aut NATIONALLICENCE 700 1- Nornes H. Department of Neurosurgery, Rikshospitalet, The National Hospital, University of Oslo, Oslo, Norway aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer-Verlag 138/1(1996-01-01), 68-76 0001-6268 138:1<68 1996 138 701 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer