caa a22 4500 47710651X CHVBK 20180405111555.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF01411724 doi (NATIONALLICENCE)springer-10.1007/BF01411724 Immune infiltrates and cytokines in gliomas [Elektronische Daten] [B. Giometto, F. Bozza, F. Faresin, L. Alessio, S. Mingrino, B. Tavolato] Summary: Frozen sections of 21 gliomas were analysed to characterize inflammatory infiltrating cells, HLA-DR antigen expression and cytokine secretion. Mononuclear cells infiltrating the tumours were mostly macrophages, which were detected in 100% of cases, and expressed HLA-DR antigens. Lymphocytes were less frequently seen and expressed the CD8 phenotype. Interleukin-1 beta (IL-1β) and Interleukin-6 (IL-6), two cytokines mainly produced by activated cells of the macrophage lineage, were demonstrated expecially in neoplastic astrocytes. IL-1β immunoreactivity was detected in all tumours, and was prevalent in more anaplastic gliomas; IL-6 was found in anaplastic gliomas and in glioblastomas. IL-1 receptors were expressed by both infiltrating macrophages and neoplastic astrocytes in the gliomas analysed. These findings suggest that cytokine production in gliomas seems not related to immune reactions against the tumour and their synthesis by anaplastic astrocytes could follow an unregulated activation of many metabolic processes after neoplastic transformation. Springer-Verlag, 1996 Glioma nationallicence macrophages nationallicence cytokines nationallicence Giometto B. Institute of Neurology Second Clinic, University of Padua, School of Medicine, Padova, Italy aut Bozza F. Institute of Neurology Second Clinic, University of Padua, School of Medicine, Padova, Italy aut Faresin F. Institute of Neurology Second Clinic, University of Padua, School of Medicine, Padova, Italy aut Alessio L. Division of Neurosurgery, University of Padua, School of Medicine, Padova, Italy aut Mingrino S. Division of Neurosurgery, University of Padua, School of Medicine, Padova, Italy aut Tavolato B. Division of Neurosurgery, University of Padua, School of Medicine, Padova, Italy aut Acta Neurochirurgica Springer-Verlag 138/1(1996-01-01), 50-56 0001-6268 138:1<50 1996 138 701 https://doi.org/10.1007/BF01411724 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01411724 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Giometto B. Institute of Neurology Second Clinic, University of Padua, School of Medicine, Padova, Italy aut NATIONALLICENCE 700 1- Bozza F. Institute of Neurology Second Clinic, University of Padua, School of Medicine, Padova, Italy aut NATIONALLICENCE 700 1- Faresin F. Institute of Neurology Second Clinic, University of Padua, School of Medicine, Padova, Italy aut NATIONALLICENCE 700 1- Alessio L. Division of Neurosurgery, University of Padua, School of Medicine, Padova, Italy aut NATIONALLICENCE 700 1- Mingrino S. Division of Neurosurgery, University of Padua, School of Medicine, Padova, Italy aut NATIONALLICENCE 700 1- Tavolato B. Division of Neurosurgery, University of Padua, School of Medicine, Padova, Italy aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer-Verlag 138/1(1996-01-01), 50-56 0001-6268 138:1<50 1996 138 701 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer