caa a22 4500 477106536 CHVBK 20180405111555.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF01411730 doi (NATIONALLICENCE)springer-10.1007/BF01411730 Endothelial-cell injury of the basilar artery caused by ethanol infusion in dogs [Elektronische Daten] [H. Kobayashi, H. Ide, M. Kabuto, Y. Handa, T. Kubota] Summary: This study in mongrel dogs was designed to observe the effects of ethanol on both endothelial cells of the basilar artery and brain function. By use of sterile surgical technique, a super-selective catheter was placed in the proximal portion of the basilar artery in the dogs. Five dogs received 3 ml of 25% ethanol and 5 dogs received 3 ml of 50% of ethanol through the catheter over 2 minutes. The remaining 5 dogs received 3 ml of saline as a control. Auditory brain stem response (ABR) was monitored for 2 hours after ethanol infusion, and then perfusion-fixation was performed from the heart with 4% paraformaldehyde. The basilar artery was observed with scanning electron microscopy after routine procedures. The endothelial cells were intact in the control group. The 50% group showed a higher level of injury to the endothelium as well as a higher degree of platelet adhesion and fibrin clot formation compared with the 25% group. The extensive endothelial-cell damage subsequently caused thrombus formation. The ABR disappeared immediately after ethanol infusion in both ethanol groups, and recovered gradually in the 25% group, but did not re-appear during the time course of 2 hours in the 50% group. The ethanol less than 25% in concentration near the endothelium is considered to be safe as a transcatheter embolic agent with the attention to the central toxicity. Springer-Verlag, 1996 Auditory brain stem response nationallicence basilar artery nationallicence ethanol nationallicence endothelial cell damage nationallicence Kobayashi H. Department of Neurosurgery, Fukui Medical School, Fukui, Japan aut Ide H. Department of Neurosurgery, Fukui Medical School, Fukui, Japan aut Kabuto M. Department of Neurosurgery, Fukui Medical School, Fukui, Japan aut Handa Y. Department of Neurosurgery, Fukui Medical School, Fukui, Japan aut Kubota T. Department of Neurosurgery, Fukui Medical School, Fukui, Japan aut Acta Neurochirurgica Springer-Verlag 138/1(1996-01-01), 84-89 0001-6268 138:1<84 1996 138 701 https://doi.org/10.1007/BF01411730 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01411730 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kobayashi H. Department of Neurosurgery, Fukui Medical School, Fukui, Japan aut NATIONALLICENCE 700 1- Ide H. Department of Neurosurgery, Fukui Medical School, Fukui, Japan aut NATIONALLICENCE 700 1- Kabuto M. Department of Neurosurgery, Fukui Medical School, Fukui, Japan aut NATIONALLICENCE 700 1- Handa Y. Department of Neurosurgery, Fukui Medical School, Fukui, Japan aut NATIONALLICENCE 700 1- Kubota T. Department of Neurosurgery, Fukui Medical School, Fukui, Japan aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer-Verlag 138/1(1996-01-01), 84-89 0001-6268 138:1<84 1996 138 701 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer