caa a22 4500 477106560 CHVBK 20180405111555.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF01411728 doi (NATIONALLICENCE)springer-10.1007/BF01411728 Increase of interleukin-6 plasma levels after elective craniotomy: Influence of interleukin-10 and catecholamines [Elektronische Daten] [M. Heesen, W. Deinsberger, G. Dietrich, O. Detsch, J. Boldt, G. Hempelmann] Summary: Accidental and operative trauma are able to induce a systemic reaction of the organism characterized by fever, leukocytosis, catabolism, and an activation of the coagulation system. Interleukin-6 (IL-6) has been found to be an important mediator of this acute-phase response. In this study the influence of elective craniotomy on IL-6 plasma levels was evaluated. Blood samples were obtained from 20 patients undergoing elective craniotorny for vascular or tumorous diseases of the brain. IL-6 increased significantly (p < 0.05) from the pre-operative (0 (0-5.4) pg/ml) to the intraoperative (180 min after beginning of surgery) time-point (10.6 (0-18.5) pg/ml). The maximum was reached on the first postoperative morning (13.9 (4.3-45.0) pg/ml). Interleukin-10 (IL-10) is an anti-inflammatory cytokine which suppresses IL-6 synthesis in vitro in various cell lines. IL-10 plasma concentrations showed no alterations throughout the study period. Epinephrine plasma concentrations increased significantly from pre-operative values (15 (0-74) pg/ml) to the postoperative time-point (57 (9-459) pg/ml). A 4.5-fold increase (p < 0.05) of norepinephrine plasma concentrations was found when comparing the data obtained 60 min after beginning of surgery with the data of the first postoperative morning. In monocytes, which are a major source of plasma IL-6, an elevation of intracellular cAMP stimulates the IL-6 synthesis. The postoperative maximum of IL-6 in plasma could be due to a release of catecholamines. In conclusion this study demonstrated an elevation of IL-6 plasma concentrations during and after elective craniotomy. Increased plasma catecholamine concentrations as well as a damage in the blood-brain barrier due to the surgical trauma with a spill-over of IL-6 from brain tissue into plasma could have contributed to this result. Springer-Verlag, 1996 Craniotomy nationallicence interleukin-6 nationallicence interleukin-10 nationallicence catecholamines nationallicence Heesen M. Department of Anaesthesiology and Intensive Care Medicine, University of Giessen, Federal Republic of Germany aut Deinsberger W. Department of Neurosurgery, University of Giessen, Federal Republic of Germany aut Dietrich G. Department of Anaesthesiology and Intensive Care Medicine, University of Giessen, Federal Republic of Germany aut Detsch O. Department of Anaesthesiology and Intensive Care Medicine, University of Giessen, Federal Republic of Germany aut Boldt J. Department of Anaesthesiology and Intensive Care Medicine, University of Giessen, Federal Republic of Germany aut Hempelmann G. Department of Anaesthesiology and Intensive Care Medicine, University of Giessen, Federal Republic of Germany aut Acta Neurochirurgica Springer-Verlag 138/1(1996-01-01), 77-80 0001-6268 138:1<77 1996 138 701 https://doi.org/10.1007/BF01411728 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01411728 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Heesen M. Department of Anaesthesiology and Intensive Care Medicine, University of Giessen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Deinsberger W. Department of Neurosurgery, University of Giessen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Dietrich G. Department of Anaesthesiology and Intensive Care Medicine, University of Giessen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Detsch O. Department of Anaesthesiology and Intensive Care Medicine, University of Giessen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Boldt J. Department of Anaesthesiology and Intensive Care Medicine, University of Giessen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Hempelmann G. Department of Anaesthesiology and Intensive Care Medicine, University of Giessen, Federal Republic of Germany aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer-Verlag 138/1(1996-01-01), 77-80 0001-6268 138:1<77 1996 138 701 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer